Antidiabetic and Antihyperlipidemic Effects of Clitocybe nuda on Glucose Transporter 4 and AMP-Activated Protein Kinase Phosphorylation in High-Fat-Fed Mice
Figure 2
Effects of the extract of Clitocybe nuda on (a) body weight at week 12, (b) body weight gain over 4-week treatment, (c) epididymal WAT weights, (d) visceral fat weight, (e) blood glucose levels, and (f) circulating triglyceride levels at week 12. Mice were fed with 45% high-fat diet (HF) or low-fat diet (CON) for 12 weeks. After 8 weeks, the HF mice were treated with vehicle (water; p.o.), extract of Clitocybe nuda, or rosiglitazone (p.o.) accompanied with HF diet for 4 weeks. All values are mean S.E. (). , , and were compared with those of the control (CON) group; , , and were compared with those of the high-fat + vehicle (distilled water) (HF) group by ANOVA. C1, C2, and C3: extracts of Clitocybe nuda (C1: 0.2, C2: 0.5, and C3: 1.0 g/kg body weight); Rosi: rosiglitazone (0.01 g/kg body weight). WAT: white adipose tissue; epididymal WAT + retroperitoneal WAT: visceral fat.
