|
| Preparations | Botanical name | Family | Medicinal part | Preparation | Vehicle | Delivery system | Observation | Effect | Mechanism of action | References |
|
| Hydroxycamptothecin (HCPT) | Camptotheca acuminata | Nyssaceae | Fruit, leave | Liposome-encapsulated 10-HCPT | Liposome | Liposome-encapsulated | In vivo
Implant | Antiproliferation of fibroblasts and reduction of epidural adhesion | Decrease of epidural scar area and fibroblast number in the epidural scar tissue | [65, 66] |
|
| Oxymatrine (OMT) | Sophora flavescens, Sophora alopecuroides, and Sophora subprostrata | Leguminosae | Unknown | Oxymatrine-phospholipid complex (OMT-PLC) | Phospholipid | Microemulsion | In vitro
In vivo
topical delivery | Antiproliferation of fibroblasts | Improvement of OMT skin permeability and increase of retention ratio of OMT in skin. | [67] |
|
| Astragaloside IV | Astragalus
membranaceus | Leguminosae | Root | Solid lipid
nanoparticle-enriched hydrogel (SLN-gel) | Lipid hydrogel | Solid lipid nanoparticle, hydrogel | In vitro
In vivo, topical delivery | Enhancement of keratinocytes migration and proliferation Increase of drug uptake in fibroblasts Promotion of wound healing and inhibition of scar formation | Caveolae endocytosis pathway. Increase of wound closure rate and angiogenesis Improvement of collagen regular organization | [68] |
|
| Ginsenoside Rg3 (G-Rg3) | Red Panax ginseng | Araliaceae | Root, rhizome | Ginsenoside Rg3/Poly (l-lactide) (G-Rg3/PLLA) | Electrospun poly
(L-lactide) fiber | Electrospun fibrous scaffolds, nanofibers | In vitro
In vivo | Inhibition of fibroblast cell growth, antiproliferation of fibroblasts, and prevention of scar formation | Improvement of dermis layer thickness, collagen fibers, and microvessels | [29] |
|
| Centella asiatica extract | Centella asiatica | Apiaceae | Whole plant | Centella asiatica extract capsule | Capsule | Nothing | In vivo | Inhibition of tissue overgrowth, reduction of scar and keloid, and anti-inflammation | Promotion of collagen I protein expression, collagen remodeling, and glycosaminoglycan synthesis Enhancement of collagen and acidic mucopolysaccharides | [69] |
|
