Ameliorating Effects of Ethanol Extract of Fructus mume on Scopolamine-Induced Memory Impairment in Mice

Figure 1

Experimental procedure. After 5-day adaption period, C57BL/6 male mice received vehicle (saline), Fructus mume (50, 100, or 200 mg/kg, p.o.), or donepezil (5 mg/kg) for 14 days. On day 8, vehicle (saline) or scopolamine (1 mg/kg, i.p.) was also administered for 7 days, and the Morris water maze task was conducted to assess cognitive function during this period (days 8–13). On day 14, each mouse was sacrificed, and the hippocampus was removed for the analysis of acetylcholinesterase activity and choline acetyltransferase expression.