Ameliorating Effects of Ethanol Extract of Fructus mume on Scopolamine-Induced Memory Impairment in Mice

Figure 2

Effect of Fructus mume on scopolamine-induced memory impairment. (a) Acquisition of spatial memory in the Morris water maze task. Vehicle control mice (VEH + VEH) were proficient in locating a hidden platform, but scopolamine-treated mice (VEH + SCO) were not (#). Scopolamine-treated mice that also received Fructus mume (F. mume) or donepezil showed better performances than those treated with scopolamine alone (). (b) Retention of spatial memory. On days 11 and 14, the probe trials were conducted 24 h after the training session. In both probe trials, vehicle control mice spent significantly more time in the target quadrant than the scopolamine-treated mice (#). In both probe trials, scopolamine-treated mice that also received F. mume showed better retention of spatial memory than those treated with scopolamine alone (). Donepezil showed significant effects on improving retention of spatial memory at the first probe trial only (). Data are expressed as mean ± standard error of the mean (SEM).

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