Ameliorating Effects of Ethanol Extract of Fructus mume on Scopolamine-Induced Memory Impairment in Mice

Figure 3

Effect of Fructus mume on hippocampal cholinergic markers in scopolamine-treated mice. (a) Hippocampal acetylcholinesterase (AChE) levels. Scopolamine-treated mice (VEH + SCO) showed higher AChE levels in the hippocampus than vehicle control mice (VEH + VEH, #). Scopolamine-treated mice that also received Fructus mume (F. mume, 200 mg/kg) or donepezil showed decreased levels of hippocampal AChE compared to mice treated with scopolamine alone (). (b) Representative western blot of choline acetyltransferase (ChAT). (c) Hippocampal ChAT levels. F. mume or donepezil treatment increased hippocampal ChAT levels (). The number in the bar graph indicates the size per group. Data are expressed as mean ± standard error of the mean (SEM).

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