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Evidence-Based Complementary and Alternative Medicine
Volume 2015, Article ID 102734, 8 pages
http://dx.doi.org/10.1155/2015/102734
Research Article

Ameliorating Effects of Ethanol Extract of Fructus mume on Scopolamine-Induced Memory Impairment in Mice

1Department of Biological Sciences, Konkuk University, Seoul 143-701, Republic of Korea
2Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 305-811, Republic of Korea
3Dongkook Pharm. Co., Ltd., R&D Center, 147 Gwanggyo-ro, Yeongtong-gu, Suwon-si, Gyeonggi-do 443-270, Republic of Korea

Received 26 September 2014; Accepted 29 December 2014

Academic Editor: Jian-Guo Chen

Copyright © 2015 Min-Soo Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. Liu, S. Yuan, Y. Sun et al., “The possible mechanisms of Fructus Mume pill in the treatment of colitis induced by 2,4,6-trinitrobenzene sulfonic acid in rats,” Journal of Ethnopharmacology, vol. 126, no. 3, pp. 557–564, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. H.-J. Choi, O.-H. Kang, P.-S. Park et al., “Mume Fructus water extract inhibits pro-inflammatory mediators in lipopolysaccharide-stimulated macrophages,” Journal of Medicinal Food, vol. 10, no. 3, pp. 460–466, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. W. K. Jeon, J. Ma, B.-R. Choi et al., “Effects of Fructus mume extract on MAPK and NF-κB signaling and the resultant improvement in the cognitive deficits induced by chronic cerebral hypoperfusion,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 450838, 13 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. H. Tomimoto, M. Ihara, H. Wakita et al., “Chronic cerebral hypoperfusion induces white matter lesions and loss of oligodendroglia with DNA fragmentation in the rat,” Acta Neuropathologica, vol. 106, no. 6, pp. 527–534, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Tsuchiya, K. Sako, S. Yura, and Y. Yonemasu, “Cerebral blood flow and histopathological changes following permanent bilateral carotid artery ligation in Wistar rats,” Experimental Brain Research, vol. 89, no. 1, pp. 87–92, 1992. View at Google Scholar · View at Scopus
  6. H. Wakita, H. Tomimoto, I. Akiguchi, and J. Kimura, “Dose-dependent, protective effect of FK506 against white matter changes in the rat brain after chronic cerebral ischemia,” Brain Research, vol. 792, no. 1, pp. 105–113, 1998. View at Publisher · View at Google Scholar · View at Scopus
  7. D. Kumaran, M. Udayabanu, M. Kumar, R. Aneja, and A. Katyal, “Involvement of angiotensin converting enzyme in cerebral hypoperfusion induced anterograde memory impairment and cholinergic dysfunction in rats,” Neuroscience, vol. 155, no. 3, pp. 626–639, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. J.-W. Ni, K. Matsumoto, H.-B. Li, Y. Murakami, and H. Watanabe, “Neuronal damage and decrease of central acetylcholine level following permanent occlusion of bilateral common carotid arteries in rat,” Brain Research, vol. 673, no. 2, pp. 290–296, 1995. View at Publisher · View at Google Scholar · View at Scopus
  9. B.-R. Choi, K. J. Kwon, S. H. Park et al., “Alternations of septal-hippocampal system in the adult wistar rat with spatial memory impairments induced by chronic cerebral hypoperfusion,” Experimental Neurobiology, vol. 20, no. 2, pp. 92–99, 2011. View at Publisher · View at Google Scholar
  10. M. G. Baxter and A. A. Chiba, “Cognitive functions of the basal forebrain,” Current Opinion in Neurobiology, vol. 9, no. 2, pp. 178–183, 1999. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Gallagher and P. J. Colombo, “Ageing: the cholinergic hypothesis of cognitive decline,” Current Opinion in Neurobiology, vol. 5, no. 2, pp. 161–168, 1995. View at Publisher · View at Google Scholar · View at Scopus
  12. D. S. Olton, “Dementia: animal models of the cognitive impairments following damage to the basal forebrain cholinergic system,” Brain Research Bulletin, vol. 25, no. 3, pp. 499–502, 1990. View at Publisher · View at Google Scholar · View at Scopus
  13. A. A. Chiba, P. J. Bushnell, W. M. Oshiro, and M. Gallagher, “Selective removal of cholinergic neurons in the basal forebrain alters cued target detection,” NeuroReport, vol. 10, no. 14, pp. 3119–3123, 1999. View at Publisher · View at Google Scholar · View at Scopus
  14. R. T. Bartus, R. L. Dean III, B. Beer, and A. S. Lippa, “The cholinergic hypothesis of geriatric memory dysfunction,” Science, vol. 217, no. 4558, pp. 408–417, 1982. View at Publisher · View at Google Scholar · View at Scopus
  15. E. Giacobini, “Cholinesterase inhibitors: new roles and therapeutic alternatives,” Pharmacological Research, vol. 50, no. 4, pp. 433–440, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. Oda, “Choline acetyltransferase: the structure, distribution and pathologic changes in the central nervous system,” Pathology International, vol. 49, no. 11, pp. 921–937, 1999. View at Publisher · View at Google Scholar · View at Scopus
  17. G. R. Dawson, C. M. Heyes, and S. D. Iversen, “Pharmacological mechanisms and animal models of cognition,” Behavioural Pharmacology, vol. 3, no. 4, pp. 285–297, 1992. View at Google Scholar · View at Scopus
  18. S. D. Iversen, “Behavioural evaluation of cholinergic drugs,” Life Sciences, vol. 60, no. 13-14, pp. 1145–1152, 1997. View at Publisher · View at Google Scholar · View at Scopus
  19. S. E. Molchan, R. A. Martinez, J. L. Hill et al., “Increased cognitive sensitivity to scopolamine with age and a perspective on the scopolamine model,” Brain Research Reviews, vol. 17, no. 3, pp. 215–226, 1992. View at Publisher · View at Google Scholar · View at Scopus
  20. H. Eichenbaum, T. Otto, and N. J. Cohen, “The hippocampus—what does it do?” Behavioral and Neural Biology, vol. 57, no. 1, pp. 2–36, 1992. View at Publisher · View at Google Scholar · View at Scopus
  21. L. R. Squire and S. M. Zola, “Structure and function of declarative and nondeclarative memory systems,” Proceedings of the National Academy of Sciences of the United States of America, vol. 93, no. 24, pp. 13515–13522, 1996. View at Publisher · View at Google Scholar · View at Scopus
  22. E. Abe, “Reversal effect of DM-9384 on scopolamine-induced acetylcholine depletion in certain regions of the mouse brain,” Psychopharmacology, vol. 105, no. 3, pp. 310–316, 1991. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Lee, J. Kim, S. G. Seo, B.-R. Choi, J.-S. Han, and K. W. Lee, “Sulforaphane alleviates scopolamine-induced memory impairment in mice,” Pharmacological Research, vol. 85, pp. 23–32, 2014. View at Publisher · View at Google Scholar · View at Scopus
  24. E. J. Shin, H. J. Hur, M. J. Sung et al., “Ethanol extract of the Prunus mume fruits stimulates glucose uptake by regulating PPAR-γ in C2C12 myotubes and ameliorates glucose intolerance and fat accumulation in mice fed a high-fat diet,” Food Chemistry, vol. 141, no. 4, pp. 4115–4121, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. Q. Jin, C. Lee, J. W. Lee, I. S. Lee, M. K. Lee, and W. K. Jeon, “Chemical constituents from the fruits of Prunus mume,” Natural Product Sciences, vol. 18, no. 3, pp. 200–203, 2012. View at Google Scholar
  26. M. Gallagher, R. Burwell, and M. Burchinal, “Severity of spatial learning impairment in aging: development of a learning index for performance in the morris water maze,” Behavioral Neuroscience, vol. 107, no. 4, pp. 618–626, 1993. View at Publisher · View at Google Scholar · View at Scopus
  27. M. D. Lindner, J. B. Hogan, D. B. Hodges Jr. et al., “Donepezil primarily attenuates scopolamine-induced deficits in psychomotor function, with moderate effects on simple conditioning and attention, and small effects on working memory and spatial mapping,” Psychopharmacology (Berl), vol. 188, no. 4, pp. 629–640, 2006. View at Publisher · View at Google Scholar · View at Scopus
  28. V. P. Prasher, “Review of donepezil, rivastigmine, galantamine and memantine for the treatment of dementia in Alzheimer's disease in adults with Down syndrome: implications for the intellectual disability population,” International Journal of Geriatric Psychiatry, vol. 19, no. 6, pp. 509–515, 2004. View at Publisher · View at Google Scholar · View at Scopus
  29. X.-T. Yan, S.-H. Lee, W. Li et al., “Evaluation of the antioxidant and anti-osteoporosis activities of chemical constituents of the fruits of Prunus mume,” Food Chemistry, vol. 156, pp. 408–415, 2014. View at Publisher · View at Google Scholar
  30. H. A. Kwon, Y.-J. Kwon, D.-Y. Kwon, and J. H. Lee, “Evaluation of antibacterial effects of a combination of Coptidis Rhizoma, Mume Fructus, and Schizandrae Fructus against Salmonella,” International Journal of Food Microbiology, vol. 127, no. 1-2, pp. 180–183, 2008. View at Publisher · View at Google Scholar · View at Scopus
  31. M. G. Giovannini, G. Spignoli, V. Carla, and G. Pepeu, “A decrease in brain catecholamines prevents oxiracetam antagonism of the effects of scopolamine on memory and brain acetylcholine,” Pharmacological Research, vol. 24, no. 4, pp. 395–405, 1991. View at Publisher · View at Google Scholar · View at Scopus
  32. S. Hirokawa, M. Nose, A. Ishige, S. Amagaya, T. Oyama, and Y. Ogihara, “Effect of Hachimi-jio-gan on scopolamine-induced memory impairment and on acetylcholine content in rat brain,” Journal of Ethnopharmacology, vol. 50, no. 2, pp. 77–84, 1996. View at Publisher · View at Google Scholar · View at Scopus
  33. Z. Dong and A. Fu, “Prevention of age-related memory deficit in transgenic mice by human choline acetyltransferase,” European Journal of Pharmacology, vol. 683, no. 1–3, pp. 174–178, 2012. View at Publisher · View at Google Scholar · View at Scopus
  34. A. L. Fu, S. J. Huang, and M. J. Sun, “Complementary remedy of aged-related learning and memory deficits via exogenous choline acetyltransferase,” Biochemical and Biophysical Research Communications, vol. 336, no. 1, pp. 268–273, 2005. View at Publisher · View at Google Scholar · View at Scopus
  35. L. Huang, T. Su, and X. Li, “Natural products as sources of new lead compounds for the treatment of Alzheimer's disease,” Current Topics in Medicinal Chemistry, vol. 13, no. 15, pp. 1864–1878, 2013. View at Publisher · View at Google Scholar · View at Scopus