The Resin from Protium heptaphyllum Prevents High-Fat Diet-Induced Obesity in Mice: Scientific Evidence and Potential Mechanisms
Table 1
Effects of Protium heptaphyllum resin (PHR) and sibutramine (SIB) treatment on body weights, net food, energy and water intake, relative weights of abdominal fat, and liver in mice fed experimental diets for 15 weeks.
Group
ND
HFD
HFD + RPH 10 mg/kg
HFD + RPH 20 mg/kg
HFD + SIB 10 mg/kg
Initial body wt (g)
25.10 ± 0.79
25.20 ± 0.55
25.20 ± 0.71
25.20 ± 0.64
25.10 ± 0.67
Final body wt (g)
40.38 ± 0.94
55.13 ± 2.35a
45.38 ± 1.29b
48.63 ± 1.47b
40.56 ± 1.35b
Net food intake (g/week)
31.65 ± 1.32
38.24 ± 3.03a
27.17 ± 1.17b
33.34 ± 1.40b
27.21 ± 1.16b
Net energy intake (kJ/mouse/day)
76.97 ± 2.89
117.06 ± 9.20a
83.03 ± 3.63b
101.86 ± 4.28
83.25 ± 3.63b
Net water intake (mL/week)
48.13 ± 0.73
47.63 ± 1.66
44.44 ± 1.20
41.91 ± 1.38
42.54 ± 0.72
Abdominal fat (mg/10 g of body wt)
195.4 ± 24.59
695.4 ± 96.60a
421.5 ± 79.22b
457.6 ± 28.38b
359.1 ± 62.21b
Liver wt (mg/10 g of body wt)
337.9 ± 13.60
413.1 ± 7.32a
378.5 ± 16.69
341.5 ± 9.56b
368.4 ± 11.54
Values are mean ± SEM (n = 8). ND: normal diet; HFD: high fat diet; RPH: resin of Protium heptaphyllum; SIB: sibutramine. aP < 0.05 versus mice fed ND; bP < 0.05 versus mice fed HFD (ANOVA followed by Student-Newman-Keuls test).