Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2015, Article ID 120785, 9 pages
http://dx.doi.org/10.1155/2015/120785
Research Article

Effect of Powdered Shells of the Snail Megalobulimus lopesi on Secondary-Intention Wound Healing in an Animal Model

1Centro de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso do Sul, 79070-900 Campo Grande, MS, Brazil
2Faculdade de Medicina Veterinária e Zootecnia, Departamento de Medicina Veterinária, Universidade Federal de Mato Grosso do Sul, 79070-900 Campo Grande, MS, Brazil
3Instituto de Química, Universidade Federal de Mato Grosso do Sul, 79074-460 Campo Grande, MS, Brazil

Received 12 August 2014; Revised 17 January 2015; Accepted 21 January 2015

Academic Editor: Gaofeng Liu

Copyright © 2015 Paulo Henrique Muleta Andrade et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. F. Builders, B. Kabele-Toge, M. Builders, B. Chindo, P. Anwunobi, and Y. Isimi, “Wound healing potential of formulated extract from hibiscus sabdariffa calyx,” Indian Journal of Pharmaceutical Sciences, vol. 75, no. 1, pp. 45–52, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. E. M. Costa-Neto, “Healing with animals in Feira de Santana City, Bahia, Brazil,” Journal of Ethnopharmacology, vol. 65, no. 3, pp. 225–230, 1999. View at Publisher · View at Google Scholar · View at Scopus
  3. F. Hajiaghaalipour, M. S. Kanthimathi, M. A. Abdulla, and J. Sanusi, “The effect of camellia sinensis on wound healing potential in an animal model,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 386734, 7 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. G. M. Cragg and D. J. Newman, “Medicinals for the millennia: the historical record,” Annals of the New York Academy of Sciences, vol. 953, pp. 3–25, 2001. View at Google Scholar · View at Scopus
  5. R. R. N. Alves and I. L. Rosa, Animals in Traditional Folk Medicine. Implications for Conservation, Springer, Berlin, Germany, 2013.
  6. G. M. Cragg and D. J. Newman, “Natural products: a continuing source of novel drug leads,” Biochimica et Biophysica Acta—General Subjects, vol. 1830, no. 6, pp. 3670–3695, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. E. M. Costa-Neto and R. R. N. Alves, “Estado da arte da zooterapia popular no,” in Zooterapia: os animais na medicina popular brasileira, E. M. Costa-Neto and R. R. N. Alves, Eds., pp. 13–54, NUPEEA, Recife, Brazil, 2010. View at Google Scholar
  8. R. R. N. Alves and I. L. Rosa, “Zootherapeutic practices among fishing communities in North and Northeast Brazil: a comparison,” Journal of Ethnopharmacology, vol. 111, no. 1, pp. 82–103, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. R. R. N. Alves, N. A. Léo Neto, G. G. Santana, W. L. S. Vieira, and W. O. Almeida, “Reptiles used for medicinal and magic religious purposes in Brazil,” Applied Herpetology, vol. 6, no. 3, pp. 257–274, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. M. P. Alfaro, D. L. Deskins, M. Wallus et al., “A physiological role for connective tissue growth factor in early wound healing,” Laboratory Investigation, vol. 93, no. 1, pp. 81–95, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. V. W. Wong and J. D. Crawford, “Vasculogenic cytokines in wound healing,” BioMed Research International, vol. 2013, Article ID 190486, 11 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. C. M. Artlett, “Inflammasomes in wound healing and fibrosis,” Journal of Pathology, vol. 229, no. 2, pp. 157–167, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. L. He and A. G. Marneros, “Macrophages are essential for the early wound healing response and the formation of a fibrovascular scar,” The American Journal of Pathology, vol. 182, no. 6, pp. 2407–2417, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. C.-L. Liu, J. C. W. Tam, A. J. Sanders et al., “Molecular angiogenic events of a two-herb wound healing formula involving MAPK and Akt signaling pathways in human vascular endothelial cells,” Wound Repair and Regeneration, vol. 21, no. 4, pp. 579–587, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. I. P. Süntar, E. K. Akkol, D. Yilmazer et al., “Investigations on the in vivo wound healing potential of Hypericum perforatum L.,” Journal of Ethnopharmacology, vol. 127, no. 2, pp. 468–477, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. Iwata, H. Akamatsu, S. Hasegawa et al., “The epidermal Integrin beta-1 and p75NTR positive cells proliferating and migrating during wound healing produce various growth factors, while the expression of p75NTR is decreased in patients with chronic skin ulcers,” Journal of Dermatological Science, vol. 71, no. 2, pp. 122–129, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. R. R. D. N. Alves, G. A. P. Filho, and Y. C. C. de Lima, “Snakes used in ethnomedicine in northeast Brazil,” Environment, Development and Sustainability, vol. 9, no. 4, pp. 455–464, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. R. M. Kunwar and R. W. Bussmann, “Ethnobotany in the nepal himalaya,” Journal of Ethnobiology and Ethnomedicine, vol. 4, article 24, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. N. Kakati, A. O. Bendang, and V. Doulo, “Indigenous knowledge of zootherapeutic use of vertebrate origin by the Ao tribe of Nagaland,” Journal Human Ecology, vol. 19, pp. 163–167, 2006. View at Google Scholar
  20. N. Mishra, S. D. Rout, and T. Panda, “Ethno-zoological studies and medicinal values of Similipal Biosphere Reserve, Orissa, India,” African Journal of Pharmacy and Pharmacology, vol. 5, no. 1, pp. 6–11, 2011. View at Google Scholar · View at Scopus
  21. A. J. A. Ranjit Singh and C. Padmalatha, “Ethnoentomological practices in Tirunelveli district, Tamil Nadu,” Indian Journal of Traditional Knowledge, vol. 3, pp. 442–446, 2004. View at Google Scholar
  22. E. M. Costa Neto and J. M. Pacheco, “Medicinal use of insects in the county of Pedra Branca, Santa Terezinha, Bahia, Brazil,” Biotemas, vol. 18, pp. 113–133, 2005. View at Google Scholar
  23. F. S. Ferreira, S. V. Brito, R. A. Saraiva et al., “Topical anti-inflammatory activity of body fat from the lizard Tupinambis merianae,” Journal of Ethnopharmacology, vol. 130, no. 3, pp. 514–520, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. E. M. Costa Neto, “Os moluscos na zooterapia: medicina tradicional e importância clínico-farmacológica,” Biotemas, vol. 19, pp. 71–78, 2006. View at Google Scholar
  25. G. Immanuel, B. J. Thaddaeus, M. Usha, R. Ramasubburayan, S. Prakash, and A. Palavesam, “Antipyretic, wound healing and antimicrobial activity of processed shell of the marine mollusc Cypraea moneta,” Asian Pacific Journal of Tropical Biomedicine, vol. 2, no. 3, pp. S1643–S1646, 2012. View at Publisher · View at Google Scholar · View at Scopus
  26. R. R. N. Alves, “Fauna used in popular medicine in Northeast Brazil,” Journal of Ethnobiology and Ethnomedicine, vol. 5, article 1, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. R. R. N. Alves, J. A. A. Barbosa, S. L. D. X. Santos, W. M. S. Souto, and R. R. D. Barboza, “Animal-based remedies as complementary medicines in the semi-arid region of northeastern Brazil,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 179876, 15 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. M. V. A. Confessor, L. E. T. Mendonça, J. S. Mourão, and R. R. N. Alves, “Animals to heal animals: ethnoveterinary practices in semiarid region, Northeastern Brazil,” Journal of Ethnobiology and Ethnomedicine, vol. 5, article 37, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. F. S. Ferreira, A. V. Brito, S. C. Ribeiro, A. A. F. Saraiva, W. O. Almeida, and R. R. N. Alves, “Animal-based folk remedies sold in public markets in Crato and Juazeiro do Norte, Ceará, Brazil,” BMC Complementary and Alternative Medicine, vol. 9, article 17, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. J. L. M. Leme, “Megalobulimus lopesi sp. n., uma nova espécie de Pulmonata terrestre da Mata Atlântica brasileira (Mollusca, Gastropoda, Megalobulimidae),” Memorando Instituto Oswaldo Cruz, Rio de Janeiro, vol. 84, pp. 313–318, 1989. View at Publisher · View at Google Scholar
  31. F. P. Ohlweiler, “Megalobulimus lopesi Leme, 1989,” in Livro vermelho da fauna brasileira ameaçada de extinção, A. B. M. Machado, G. M. Drummond, and A. P. Paglia, Eds., pp. 472–473, Ministério do Meio Ambiente, Brasília, Brazil, 2008. View at Google Scholar
  32. P. C. Marinho, R. Neto-Ferreira, and J. José De Carvalho, “Evaluation of therapeutic intervention with a natural product in Cutaneous wound healing: The use of capybara oil,” Evidence-based Complementary and Alternative Medicine, vol. 2013, Article ID 217198, 10 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  33. G. E. P. de Souza and S. H. Ferreira, “Blockade by anti-macrophage serum of the migration of PMN neutrophils into the inflamed peritoneal cavity,” Agents and Actions, vol. 17, no. 1, pp. 97–103, 1985. View at Publisher · View at Google Scholar · View at Scopus
  34. M. M. Bradford, “A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding,” Analytical Biochemistry, vol. 72, no. 1-2, pp. 248–254, 1976. View at Publisher · View at Google Scholar · View at Scopus
  35. U. K. Laemmli, “Cleavage of structural proteins during the assembly of the head of bacteriophage T4,” Nature, vol. 227, no. 5259, pp. 680–685, 1970. View at Publisher · View at Google Scholar · View at Scopus
  36. G. Benítez, “Animals used for medicinal and magico-religious purposes in western Granada Province, Andalusia (Spain),” Journal of Ethnopharmacology, vol. 137, no. 3, pp. 1113–1123, 2011. View at Publisher · View at Google Scholar · View at Scopus
  37. D. S. Bhakuni and D. S. Rawat, Bioactive Marine Natural Products, Springer, New York, NY, USA, 2005.
  38. B. Haefner, “Drugs from the deep: marine natural products as drug candidates,” Drug Discovery Today, vol. 8, no. 12, pp. 536–544, 2003. View at Publisher · View at Google Scholar · View at Scopus
  39. T. Børresen, “Seafood for improved health and wellbeing,” Food Technology, vol. 63, no. 1, p. 88, 2009. View at Google Scholar · View at Scopus
  40. S. Q. Wasman, A. A. Mahmood, H. Salehhuddin, A. A. Zahra, and I. Salmah, “Cytoprotective activities of Polygonum minus aqueous leaf extract on ethanol-induced gastric ulcer in rats,” Journal of Medicinal Plants Research, vol. 4, no. 24, pp. 2658–2665, 2010. View at Google Scholar · View at Scopus
  41. J. Li, J. Chen, and R. Kirsner, “Pathophysiology of acute wound healing,” Clinics in Dermatology, vol. 25, no. 1, pp. 9–18, 2007. View at Publisher · View at Google Scholar · View at Scopus
  42. B. Romana-Souza, A. P. Nascimento, and A. Monte-Alto-Costa, “Propranolol improves cutaneous wound healing in streptozotocin-induced diabetic rats,” European Journal of Pharmacology, vol. 611, no. 1–3, pp. 77–84, 2009. View at Publisher · View at Google Scholar · View at Scopus
  43. H. A. Thomason, N. H. Cooper, D. M. Ansell et al., “Direct evidence that PKCá positively regulates wound re-epithelialization: correlation with changes in desmosomal adhesiveness,” Journal of Pathology, vol. 227, no. 3, pp. 346–356, 2012. View at Publisher · View at Google Scholar · View at Scopus
  44. L. A. Schneider, A. Korber, S. Grabbe, and J. Dissemond, “Influence of pH on wound-healing: a new perspective for wound-therapy?” Archives of Dermatological Research, vol. 298, no. 9, pp. 413–420, 2007. View at Publisher · View at Google Scholar · View at Scopus
  45. A. B. G. Lansdown, “Calcium: a potential central regulator in wound healing in the skin,” Wound Repair and Regeneration, vol. 10, no. 5, pp. 271–285, 2002. View at Publisher · View at Google Scholar · View at Scopus
  46. M. Limova, “Evaluation of two calcium alginate dressings in the management of venous ulcers,” Ostomoy Wound Manage, vol. 49, pp. 26–33, 2003. View at Google Scholar
  47. C. Joubert, D. Piquemal, B. Marie et al., “Transcriptome and proteome analysis of Pinctada margaritifera calcifying mantle and shell: focus on biomineralization,” BMC Genomics, vol. 11, article 613, 2010. View at Publisher · View at Google Scholar · View at Scopus
  48. F. Marin, B. Marie, S. B. Hamada et al., “‘Shellome’: proteins involved in mollusk shell biomineralization—diversity, functions,” in International Symposium on Pearl Research, vol. 15, pp. 149–166, 2012.
  49. S. Berland, A. Marie, D. Duplat, C. Milet, J. Y. Sire, and L. Bédouet, “Coupling proteomics and transcriptomics for the identification of novel and variant forms of mollusk shell proteins: a study with P. margaritifera,” ChemBioChem, vol. 12, no. 6, pp. 950–961, 2011. View at Publisher · View at Google Scholar · View at Scopus
  50. S. J. Hattan, T. M. Laue, and N. D. Chasteen, “Purification and characterization of a novel calcium-binding protein from the extrapallial fluid of the mollusc, mytilus edulis,” Journal of Biological Chemistry, vol. 276, no. 6, pp. 4461–4468, 2001. View at Publisher · View at Google Scholar · View at Scopus
  51. B. Marie, A. Marie, D. J. Jackson et al., “Proteomic analysis of the organic matrix of the abalone Haliotis asinina calcified shell,” Proteome Science, vol. 8, article 54, 2010. View at Publisher · View at Google Scholar · View at Scopus
  52. R. K. Jha and Z. R. Xu, “Biomedical compounds from marine organisms,” Marine Drugs, vol. 2, no. 3, pp. 123–146, 2004. View at Publisher · View at Google Scholar
  53. K. Senni, J. Pereira, F. Gueniche et al., “Marine polysaccharides: a source of bioactive molecules for cell therapy and tissue engineering,” Marine Drugs, vol. 9, no. 9, pp. 1664–1681, 2011. View at Publisher · View at Google Scholar · View at Scopus
  54. I. M. Weiss, W. Göhring, M. Fritz, and K. Mann, “Perlustrin, a Haliotis laevigata (abalone) nacre protein, is homologous to the insulin-like growth factor binding protein N-terminal module of vertebrates,” Biochemical and Biophysical Research Communications, vol. 285, no. 2, pp. 244–249, 2001. View at Publisher · View at Google Scholar · View at Scopus