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Primary
author | Study design and blinding type | Primary outcome | Sample allocation and profile | Sample loss and calculation | Test product masking | Pilot study and examiner calibration | Control group characterization | Test product pharmaceutical form, concentration, and usage time |
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Wright
[13] | Randomized controlled clinical trial.
Study was not blind. | Treatment of oral candidiasis: clinical regression of lesions. | 90 patients with HIV/AIDS in a sanatorium. These patients were diagnosed with oral candidiasis and were not being treated for this purpose.
Not mentioned: sample allocation. | The study began with 90 patients and finished with 52.
Not mentioned: calculation. | There was no masking. | Not mentioned: pilot study and examiner calibration. | Gentian violet aqueous solution (0.5%).
Painted on the inside of the mouth three times daily for 10 days. | Lemon juice (experimental treatment 1) for 10 days or until clinical cure; lemon grass (experimental treatment 2) for 10 days. Not mentioned: concentrations. |
|
Bakhshi
[3] | Controlled randomized double-blind clinical trial.
Not mentioned: the blinding of study subjects. | Treatment of stomatitis under denture: clinical reduction of lesions after mouthwash. | 40 institutionalized elderly subjects diagnosed with denture stomatitis.
Not mentioned: sample allocation. | Not mentioned: calculation and loss. | Garlic aqueous solution and nystatin mouthwash were in similar bottles with the same shape, size, and color. Not mentioned: masking of smell, color, and taste. | Not mentioned: pilot study and examiner calibration. | Nystatin mouthwash (100,000 U/mL).
Swish 20 drops for 60 seconds, three times a day. | Garlic aqueous solution
(40 mg/mL) for 4 weeks. |
|
Amanlou
[2] | Randomized controlled triple-blind clinical trial. | Treatment of stomatitis under denture associated with Candida: reduction of clinical signs and symptoms and microbiological findings. | 24 users of dentures diagnosed with denture stomatitis (clinical and microbiological), aged between 45 and 83 years.
Not mentioned: sample allocation. | Not mentioned: calculation and loss. | Masking of smell, color, and taste as much as possible. | Not mentioned: pilot study and examiner calibration. | Miconazole 2% gel.
Apply 2.5 mL on the base of the denture and place it in, four times a day for a period of 2 weeks. | Z. multiflora essential oil
0.1% gel for 2 weeks. |
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