Review Article

Does Scientific Evidence for the Use of Natural Products in the Treatment of Oral Candidiasis Exist? A Systematic Review

Table 2

Data collection, statistical analysis, results, and conclusions.

Primary
author
Initial comparison between groupsCriteria for diagnosisFollow-up treatmentStatistical analysisAnalysis of results and conclusions

Wright [13]Age, gender, BMI, oral candidiasis scale on the day of admission, and number of days with symptoms were compared, and no difference between groups was observed.Oral candidiasis was diagnosed and characterized from a 0 to 4 scale, where 0 represents no disease and 4 severe degree (oral thrush scale).Once the patients were institutionalized, the treatment was controlled by nurses. Data were gathered as ordinal data and analyzed by the following statistical tests: Fisher’s exact test, chi-square test, and chi-square test with the continuity correction and the likelihood ratio.
Level of significance: 95%.
Whether the sample was adequate is unknown because the author does not mention sample calculations.
The quality of the analysis is doubtful due to the test selection.
The choice of statistical test was inadequate for the ordinal data.
The conclusion answers the aims.

Bakhshi [3]The groups were compared regarding the methods used for cleansing dentures and the size of erythematous lesions present before treatment. No significant difference was observed between groups.Diagnosis was established by measuring the length and width of erythematous lesions underneath the dentures by an oral medicine specialist using an oral caliper.Not mentioned: daily monitoring to assess adherence to treatment and the correct use of the products. ANOVA repeated measures + LSD post hoc test.
Chi-square test is mentioned in the methodology but is not referred to in the results or in the analysis itself.
The level of significance is not mentioned specifically. In the results, we find references for 99.9% and 99.99%.
The analysis is accurate because the tests chosen are suitable for the type of obtained data.
However, whether the sample was adequate is unknown because the author does not mention sample calculations.
The conclusion answers the aims.

Amanlou [2]The groups were compared in terms of age, gender, history of systemic disease, and detection of C. albicans on denture surfaces and palatal sample. No significant difference was observed between groups.Erythematous denture, covered palatal mucosa graded as moderate or severe.
Diagnosed candidiasis was confirmed by microbiologic cultures from the palatal mucosa and from the denture surface.
There is no information regarding adherence to treatment or follow-up to control the proper use of medication. Chi-square analysis, Student’s -test, and Mann-Whitney test for independent samples.
Level of significance: 95%.
Whether the sample was adequate is unknown because the author does not mention sample calculations.
We cannot affirm the accuracy of the statistical analysis because the text does not mention a test to assess paired ordinal data and because the mentioned tests do not cover the entire analysis.
The conclusion answers the aims.