Tocotrienol-Rich Fraction from Rice Bran Demonstrates Potent Radiation Protection Activity

Figure 4

Pretreatment with 5 μM DT3 or TRFRB preserved the cellular bioenergetics and mitochondrial respiration of H9c2 cells following injury. Treatment of both DT3 and TRFRB increased basal oxygen consumption rate (OCR) as well as maximum OCR in H9c2 rat heart cardiomyocytes (a). Treatment with 5 μM of DT3 or TRFRB prior to 50 (b) or 100 μM (c) resulted in complete protection and restored the mitochondrial respiration. Each data point represents mean ± SEM of wells from 2 separate experiments. as compared to control, as compared to treated group.

(a)

(b)

(c)