Germinated Brown Rice Alters Aβ(1-42) Aggregation and Modulates Alzheimer’s Disease-Related Genes in Differentiated Human SH-SY5Y Cells

Figure 1

Antiamyloidogenic properties of GBR. (a) 20 μM Aβ(1-42) incubated for 48 h at 37°C under near-physiological conditions assembled into negatively stained amyloid fibrils. (b and c) 20 μM Aβ(1-42) in the presence of 1 ppm and 10 ppm of GBR, respectively, incubated for 48 h at 37°C under near-physiological conditions formed amorphous positively stained deposits showing remnants of a fibril-like morphology. TEM images with 10kx magnification with scale bar = 200 nm and 20kx magnification with scale bar = 100 nm.

(a) Aβ(1-42)

(b) Aβ(1-42) + GBR 1 ppm

(c) Aβ(1-42) + GBR 10 ppm