Panax notoginseng Saponins Attenuate Phenotype Switching of Vascular Smooth Muscle Cells Induced by Notch3 Silencing

Figure 1

TRITC labeled phalloidin staining showing actin cytoskeleton of VSMCs. Under the excitation wavelength of 488 nm, the cytoskeletons of control and Notch3 siRNA VSMCs were reddish-yellow and the GFP dots were green in the cytoplasm. Notch3 siRNA VSMCs are more rounded and irregular and lack actin cytoskeleton. Upon treatment with PNS, VSMCs became regular.