The Flavonoid Apigenin Ameliorates Cisplatin-Induced Nephrotoxicity through Reduction of p53 Activation and Promotion of PI3K/Akt Pathway in Human Renal Proximal Tubular Epithelial Cells

<div>The effects of apigenin on cell morphology and cell cycle progression in cisplatin-treated HK-2 cells. Cells were treated with 40 <i>μ</i>M of cisplatin for 24 h in the absence or presence of 20 <i>μ</i>M of apigenin (pretreatment for 1 h). Cell morphology was observed using an inverted microscope (a). Cell cycle progression was analyzed by a flow cytometry (b).</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 2: The Flavonoid Apigenin Ameliorates Cisplatin-Induced Nephrotoxicity through Reduction of p53 Activation and Promotion of PI3K/Akt Pathway in Human Renal Proximal Tubular Epithelial Cells 

Figure 2 | The Flavonoid Apigenin Ameliorates Cisplatin-Induced Nephrotoxicity through Reduction of p53 Activation and Promotion of PI3K/Akt Pathway in Human Renal Proximal Tubular Epithelial Cells 