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Evidence-Based Complementary and Alternative Medicine
Volume 2015, Article ID 187346, 8 pages
http://dx.doi.org/10.1155/2015/187346
Research Article

Pharmacological and Genotoxic Properties of Polyphenolic Extracts of Cedrela odorata L. and Juglans regia L. Barks in Rodents

1CIIDIR-IPN Unidad Durango, Sigma 119 Fraccionamiento 20 de Noviembre, 34220 Durango, DGO, Mexico
2Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Wilfrido Massieu s/n, Esquina Manuel L. Stampa, Colonia Unidad Profesional Adolfo López Mateos, Delegación Gustavo A. Madero, 07738 Ciudad de México, DF, Mexico

Received 4 January 2015; Revised 28 February 2015; Accepted 18 March 2015

Academic Editor: Michał Tomczyk

Copyright © 2015 Dulce Carolina Almonte-Flores et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Carvalho, P. J. Ferreira, V. S. Mendes et al., “Human cancer cell antiproliferative and antioxidant activities of Juglans regia L,” Food and Chemical Toxicology, vol. 48, no. 1, pp. 441–447, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. A. A. Kale, A. G. Sucheta, S. K. Gayatri, N. R. Deshpande, and J. P. Salvekar, “In vitro anthelmintic activity of stem bark of Juglans regia L.,” Journal of Chemical and Pharmaceutical Research, vol. 3, no. 2, pp. 298–302, 2011. View at Google Scholar · View at Scopus
  3. A. Tahraoui, J. El-Hilaly, Z. H. Israili, and B. Lyoussi, “Ethnopharmacological survey of plants used in the traditional treatment of hypertension and diabetes in south-eastern Morocco (Errachidia province),” Journal of Ethnopharmacology, vol. 110, no. 1, pp. 105–117, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. K. Rashed, C. Ching-Wen, W. Lung-Yuan, and P. Wen-Huang, “Hepatoprotective effect from Cedrela odorata and phytochemical profile,” Journal of Pharmaceutical and Cosmetic Sciences, vol. 1, pp. 45–52, 2013. View at Google Scholar
  5. N. T. Kipassa, T. Iwagawa, H. Okamura, M. Doe, Y. Morimoto, and M. Nakatani, “Limonoids from the stem bark of Cedrela odorata,” Phytochemistry, vol. 69, no. 8, pp. 1782–1787, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. I. Ignat, I. Volf, and V. I. Popa, “A critical review of methods for characterisation of polyphenolic compounds in fruits and vegetables,” Food Chemistry, vol. 126, no. 4, pp. 1821–1835, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. S. Luqman, S. Kaushik, S. Srivastava et al., “Protective effect of medicinal plant extracts on biomarkers of oxidative stress in erythrocytes,” Pharmaceutical Biology, vol. 47, no. 6, pp. 483–490, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. J. S. Amaral, R. M. Seabra, P. B. Andrade, P. Valentão, J. A. Pereira, and F. Ferreres, “Phenolic profile in the quality control of walnut (Juglans regia L.) leaves,” Food Chemistry, vol. 88, no. 3, pp. 373–379, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Matić, S. Stanić, D. Bogojević et al., “Methanol extract from the stem of Cotinus coggygria Scop., and its major bioactive phytochemical constituent myricetin modulate pyrogallol-induced DNA damage and liver injury,” Mutation Research—Genetic Toxicology and Environmental Mutagenesis, vol. 755, no. 2, pp. 81–89, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Petriccione and C. Ciniglia, “Comet assay to assess the genotoxicity of persian walnut (Juglans regia L.) husks with statistical evaluation,” Bulletin of Environmental Contamination and Toxicology, vol. 89, no. 1, pp. 166–171, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. B. Burlinson, R. R. Tice, G. Speit et al., “Fourth International Workgroup on Genotoxicity testing: results of the in vivo Comet assay workgroup,” Mutation Research/Genetic Toxicology and Environmental Mutagenesis, vol. 627, no. 1, pp. 31–35, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. R. R. Tice, E. Agurell, D. Anderson et al., “Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing,” Environmental and Molecular Mutagenesis, vol. 35, no. 3, pp. 206–221, 2000. View at Google Scholar
  13. A. B. C. R. Alves, R. S. D. Santos, S. D. S. Calil et al., “Genotoxic assessment of Rubus imperialis (Rosaceae) extract in vivo and its potential chemoprevention against cyclophosphamide-induced DNA damage,” Journal of Ethnopharmacology, vol. 153, no. 3, pp. 694–700, 2014. View at Publisher · View at Google Scholar · View at Scopus
  14. M. A. Giordani, T. C. Collicchio, S. D. Ascêncio et al., “Hydroethanolic extract of the inner stem bark of Cedrela odorata has low toxicity and reduces hyperglycemia induced by an overload of sucrose and glucose,” Journal of Ethnopharmacology, vol. 162, pp. 352–361, 2015. View at Publisher · View at Google Scholar
  15. P. Waterman and S. Mole, Analysis of Phenolic Plant Metabolites: Methods in Ecology, Blackwell Scientific Publications, Boston, Mass, USA, 1994.
  16. M. Rosales-Castro, R. F. González-Laredo, N. E. Rocha-Guzmán, J. A. Gallegos-Infante, M. J. María José Rivas-Arreola, and J. J. Karchesy, “Antioxidant activity of fractions from Quercus sideroxyla bark and identification of proanthocyanidins by HPLC-DAD and HPLC-MS,” Holzforschung, vol. 66, no. 5, pp. 577–584, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. W. Brand-Williams, M. E. Cuvelier, and C. Berset, “Use of a free radical method to evaluate antioxidant activity,” LWT—Food Science and Technology, vol. 28, no. 1, pp. 25–30, 1995. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Rosales-Castro, R. González-Laredo, N. Rocha-Guzmán et al., “Chromatographic analysis of bioactive proanthocyanidins from Quercus durifolia and Quercus eduardii barks,” Acta Chromatographica, vol. 23, no. 3, pp. 521–529, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. R. Pérez, R. Vargas, F. Martínez, E. García, and B. Hernández, “Antioxidant activity of alkaloids from Bocconia arborea. A study on six testing methods,” Ars Pharmaceutica, vol. 44, pp. 5–21, 2003. View at Google Scholar
  20. A. K. Khanna, F. Rizvi, and R. Chander, “Lipid lowering activity of Phyllanthus niruri in hyperlipemic rats,” Journal of Ethnopharmacology, vol. 82, no. 1, pp. 19–22, 2002. View at Publisher · View at Google Scholar · View at Scopus
  21. F. Rivera-Ramírez, G. N. Escalona-Cardoso, L. Garduño-Siciliano, C. Galaviz-Hernández, and N. Paniagua-Castro, “Antiobesity and hypoglycaemic effects of aqueous extract of Ibervillea sonorae in mice fed a high-fat diet with fructose,” Journal of Biomedicine and Biotechnology, vol. 2011, Article ID 968984, 6 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Čabarkapa, L. Živković, D. Žukovec et al., “Protective effect of dry olive leaf extract in adrenaline induced DNA damage evaluated using in vitro comet assay with human peripheral leukocytes,” Toxicology in Vitro, vol. 28, no. 3, pp. 451–456, 2014. View at Publisher · View at Google Scholar · View at Scopus
  23. Z. Zhang, L. Liao, J. Moore, T. Wu, and Z. Wang, “Antioxidant phenolic compounds from walnut kernels (Juglans regiaL.),” Food Chemistry, vol. 113, no. 1, pp. 160–165, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. H. Ahmad, I. Khan, and A. Wahid, “Antiglycation and antioxidation properties of Juglans regia and Calendula officinalis: possible role in reducing diabetic complications and slowing down ageing,” Journal of Traditional Chinese Medicine, vol. 32, no. 3, pp. 411–414, 2012. View at Publisher · View at Google Scholar · View at Scopus
  25. A. P. Rauter, A. Martins, C. Borges et al., “Antihyperglycaemic and protective effects of flavonoids on streptozotocin-induced diabetic rats,” Phytotherapy Research, vol. 24, supplement 2, pp. S133–S138, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. P. Bansal, P. Paul, J. Mudgal et al., “Antidiabetic, antihyperlipidemic and antioxidant effects of the flavonoid rich fraction of Pilea microphylla (L.) in high fat diet/streptozotocin-induced diabetes in mice,” Experimental and Toxicologic Pathology, vol. 64, no. 6, pp. 651–658, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. S. Ramachandran, K. R. Naveen, B. Rajinikanth, M. Akbar, and A. Rajasekaran, “Antidiabetic, antihyperlipidemic and in vivo antioxidant potential of aqueous extract of Anogeissus latifolia bark in type 2 diabetic rats,” Asian Pacific Journal of Tropical Disease, vol. 2, no. 2, pp. S596–S602, 2012. View at Publisher · View at Google Scholar · View at Scopus