Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2015, Article ID 189891, 13 pages
http://dx.doi.org/10.1155/2015/189891
Research Article

Evaluation of an Epitypified Ophiocordyceps formosana (Cordyceps s.l.) for Its Pharmacological Potential

1Department of Plant Pathology and Microbiology, National Taiwan University, Taipei 10617, Taiwan
2Mucho Biotechnology Inc., Taipei 10684, Taiwan
3Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan
4Department of Animal Science and Technology, National Taiwan University, Taipei 10672, Taiwan
5Center for Biotechnology, National Taiwan University, Taipei 10617, Taiwan
6Laboratory of Molecular Cell Biology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan
7Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan

Received 10 March 2015; Revised 13 July 2015; Accepted 16 July 2015

Academic Editor: Min Li

Copyright © 2015 Yen-Wen Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C.-Q. Ling, X.-Q. Yue, and C. Ling, “Three advantages of using traditional Chinese medicine to prevent and treat tumor,” Journal of Integrative Medicine, vol. 12, no. 4, pp. 331–335, 2014. View at Publisher · View at Google Scholar · View at Scopus
  2. J. Wang, Y.-M. Liu, W. Cao, K.-W. Yao, Z.-Q. Liu, and J.-Y. Guo, “Anti-inflammation and antioxidant effect of cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis, in middle cerebral artery occlusion-induced focal cerebral ischemia in rats,” Metabolic Brain Disease, vol. 27, no. 2, pp. 159–165, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. B. Shi, Z. Wang, H. Jin, Y. W. Chen, Q. Wang, and Y. Qian, “Immunoregulatory Cordyceps sinensis increases regulatory T cells to Th17 cell ratio and delays diabetes in NOD mice,” International Immunopharmacology, vol. 9, no. 5, pp. 582–586, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. N. Manabe, Y. Azuma, M. Sugimoto et al., “Effects of the mycelial extract of cultured Cordyceps sinensis on in vivo hepatic energy metabolism and blood flow in dietary hypoferric anaemic mice,” British Journal of Nutrition, vol. 83, no. 2, pp. 197–204, 2000. View at Google Scholar · View at Scopus
  5. T. Jayakumar, C.-C. Chiu, S.-H. Wang, D.-S. Chou, Y.-K. Huang, and J.-R. Sheu, “Anti-cancer effects of CME-1, a novel polysaccharide, purified from the mycelia of Cordyceps sinensis against B16-F10 melanoma cells,” Journal of Cancer Research and Therapeutics, vol. 10, no. 1, pp. 43–49, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. H.-Y. Pao, B.-S. Pan, S.-F. Leu, and B.-M. Huang, “Cordycepin stimulated steroidogenesis in MA-10 mouse Leydig tumor cells through the protein kinase C pathway,” Journal of Agricultural and Food Chemistry, vol. 60, no. 19, pp. 4905–4913, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Sato, N. Yoshikawa, E. Kubo et al., “Inhibitory effect of cordycepin on experimental hepatic metastasis of B16-F0 mouse melanoma cells,” In Vivo, vol. 27, no. 6, pp. 729–732, 2013. View at Google Scholar · View at Scopus
  8. J. Y. Wu, Q. X. Zhang, and P. H. Leung, “Inhibitory effects of ethyl acetate extract of Cordyceps sinensis mycelium on various cancer cells in culture and B16 melanoma in C57BL/6 mice,” Phytomedicine, vol. 14, no. 1, pp. 43–49, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. T. Ramesh, S.-K. Yoo, S.-W. Kim et al., “Cordycepin (3′-deoxyadenosine) attenuates age-related oxidative stress and ameliorates antioxidant capacity in rats,” Experimental Gerontology, vol. 47, no. 12, pp. 979–987, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. F. A. Faisal, D. Sundi, J. L. Cooper et al., “Racial disparities in oncologic outcomes after radical prostatectomy: long-term follow-up,” Urology, vol. 84, no. 6, pp. 1434–1441, 2014. View at Publisher · View at Google Scholar · View at Scopus
  11. I. N. Tiurenkov, E. V. Volotova, D. V. Kurkin, D. A. Bakulin, I. O. Logvinov, and T. A. Antipova, “Neuroprotective effect of neuroglutam under conditions of activated free radical oxidation,” Eksperimental'naia i Klinicheskaia Farmakologiia, vol. 77, no. 8, pp. 16–19, 2014. View at Google Scholar · View at Scopus
  12. K. Matsui, Y. Kawaguchi, T. Ozaki et al., “Effect of active hexose correlated compound on the production of nitric oxide in hepatocytes,” Journal of Parenteral and Enteral Nutrition, vol. 31, no. 5, pp. 373–380, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. E.-S. Park, D.-H. Kang, M.-K. Yang et al., “Cordycepin, 3′-deoxyadenosine, prevents rat hearts from ischemia/reperfusion injury via activation of Akt/GSK-3β/p70S6K signaling pathway and HO-1 expression,” Cardiovascular Toxicology, vol. 14, no. 1, pp. 1–9, 2014. View at Publisher · View at Google Scholar · View at Scopus
  14. D.-B. Ji, J. Ye, C.-L. Li, Y.-H. Wang, J. Zhao, and S.-Q. Cai, “Antiaging effect of Cordyceps sinensis extract,” Phytotherapy Research, vol. 23, no. 1, pp. 116–122, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. S. P. Li, K. J. Zhao, Z. N. Ji et al., “A polysaccharide isolated from Cordyceps sinensis, a traditional Chinese medicine, protects PC12 cells against hydrogen peroxide-induced injury,” Life Sciences, vol. 73, no. 19, pp. 2503–2513, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. Kobayasi, “The genus Cordyceps and its allies,” Science Reports of the Tokyo Bunrika Daigaku Section B, vol. 5, no. 84, pp. 53–260, 1941. View at Google Scholar
  17. Y. Kobayasi, “Keys to the taxa of the genera Cordyceps and Torrubiella,” Transaction of the Mycological Society of Japan, vol. 23, pp. 329–364, 1982. View at Google Scholar
  18. E. B. Mains, “North American entomogenous species of Cordyceps,” Mycologia, vol. 50, no. 2, pp. 169–222, 1958. View at Publisher · View at Google Scholar
  19. C. L. Schoch, K. A. Seifert, S. Huhndorf et al., “Nuclear ribosomal internal transcribed spacer (ITS) region as a universal DNA barcode marker for fungi,” Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 16, pp. 6241–6246, 2012. View at Publisher · View at Google Scholar
  20. Y. Tanabe, M. Saikawa, M. M. Watanabe, and J. Sugiyama, “Molecular phylogeny of Zygomycota based on EF-1α and RPB1 sequences: limitations and utility of alternative markers to rDNA,” Molecular Phylogenetics and Evolution, vol. 30, no. 2, pp. 438–449, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. G.-H. Sung, N. L. Hywel-Jones, J.-M. Sung, J. J. Luangsa-ard, B. Shrestha, and J. W. Spatafora, “Phylogenetic classification of Cordyceps and the clavicipitaceous fungi,” Studies in Mycology, vol. 57, pp. 5–59, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. Y. Kobayasi, “The genus Cordyceps and its allies from Taiwan (Formosa),” Bulletin of the National Science Museum. Series B (Tokyo), vol. 7, no. 4, pp. 113–122, 1981. View at Google Scholar
  23. S.-M. Chou, W.-J. Lai, T.-W. Hong et al., “Synergistic property of cordycepin in cultivated Cordyceps militaris-mediated apoptosis in human leukemia cells,” Phytomedicine, vol. 21, no. 12, pp. 1516–1524, 2014. View at Publisher · View at Google Scholar · View at Scopus
  24. J. J. Doyle, “Isolation of plant DNA from fresh tissue,” Focus, vol. 12, pp. 13–15, 1990. View at Google Scholar
  25. L. A. Castlebury, A. Y. Rossman, G.-H. Sung, A. S. Hyten, and J. W. Spatafora, “Multigene phylogeny reveals new lineage for Stachybotrys chartarum, the indoor air fungus,” Mycological Research, vol. 108, no. 8, pp. 864–872, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. Y. J. Liu, S. Whelen, and B. D. Hall, “Phylogenetic relationships among ascomycetes: evidence from an RNA polymerse II subunit,” Molecular Biology and Evolution, vol. 16, no. 12, pp. 1799–1808, 1999. View at Publisher · View at Google Scholar · View at Scopus
  27. S. A. Rehner and E. Buckley, “A Beauveria phylogeny inferred from nuclear ITS and EF1-α sequences: evidence for cryptic diversification and links to Cordyceps teleomorphs,” Mycologia, vol. 97, no. 1, pp. 84–98, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. K. Tamura, G. Stecher, D. Peterson, A. Filipski, and S. Kumar, “MEGA6: molecular evolutionary genetics analysis version 6.0,” Molecular Biology and Evolution, vol. 30, no. 12, pp. 2725–2729, 2013. View at Publisher · View at Google Scholar · View at Scopus
  29. A. Stamatakis, “RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models,” Bioinformatics, vol. 22, no. 21, pp. 2688–2690, 2006. View at Publisher · View at Google Scholar · View at Scopus
  30. J. Mondal, K. Bishayee, A. K. Panigrahi, and A. R. Khuda-Bukhsh, “Low doses of ethanolic extract of Boldo (Peumus boldus) can ameliorate toxicity generated by cisplatin in normal liver cells of mice in vivo and in WRL-68 cells in vitro, but not in cancer cells in vivo or in vitro,” Journal of Integrative Medicine, vol. 12, no. 5, pp. 425–438, 2014. View at Publisher · View at Google Scholar · View at Scopus
  31. S. Saha, F. Hossain, M. Anisuzzman, and M. K. Islam, “Pharmacological evaluation of Musa seminifera Lour. fruit,” Journal of Integrative Medicine, vol. 11, no. 4, pp. 253–261, 2013. View at Publisher · View at Google Scholar · View at Scopus
  32. P.-Y. Chu, T.-K. Li, S.-T. Ding, I.-R. Lai, and T.-L. Shen, “EGF-induced Grb7 recruits and promotes ras activity essential for the tumorigenicity of Sk-Br3 breast cancer cells,” The Journal of Biological Chemistry, vol. 285, no. 38, pp. 29279–29285, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. K.-H. Lu, Y.-F. Chang, P.-H. Yin et al., “In vitro and in vivo apoptosis-inducing antileukemic effects of Mucuna macrocarpa stem extract on HL-60 human leukemia cells,” Integrative Cancer Therapies, vol. 9, no. 3, pp. 298–308, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. H. H. Ku, “Notes on the use of propagation of error formulas,” Journal of Research of the National Bureau of Standards, vol. 70, no. 4, pp. 263–273, 1966. View at Google Scholar
  35. Y.-Z. Wang and W.-N. Chou, Investigation of the Environmental and Ecological Indicators—The Research Report for Guanwu Mushroom, Shei-Pa National Park, Construction and Planning Agency Ministry of the Interior, Taichung, Taiwan, 2004.
  36. C.-R. Li, C.-R. Xia, Y.-R. Lin, M.-Z. Fan, and Z.-Z. Li, “Hirsutella huangshanensis sp. nov. The anamorph of Cordyceps formosana and its infection on Tenebrio molitor,” Mycosystema, vol. 24, no. 3, pp. 349–355, 1985. View at Google Scholar
  37. E. B. Mains, “Cordyceps Stylophora and Cordyceps ravenelii,” Mycologia, vol. 33, no. 6, pp. 611–617, 1941. View at Publisher · View at Google Scholar
  38. Y. Kobayasi, “Cordyceps species from Japan 6,” Bulletin of the National Science Museum, Series B (Tokyo), vol. 9, no. 1, pp. 1–21, 1983. View at Google Scholar
  39. Y. Kobayasi and D. Shimizu, “Cordyceps species from Japan 2,” Bulletin of the National Science Museum Tokyo Series B, vol. 6, no. 3, pp. 77–96, 1980. View at Google Scholar
  40. I. A. Gorbunova, V. Y. Kryukov, and E. G. Zibzeev, “First records of the entomopathogenic fungus Ophiocordyceps gracilis (Ascomycota, Hypocreales) from Siberia,” Euroasian Entomological Journal, vol. 10, no. 1, pp. 17–18, 2011. View at Google Scholar
  41. Y. Kobayasi, “On the genus Cordyceps and its allies on cicadae from Japan,” Bulletin of the Biogeographical Society of Japan, vol. 9, pp. 145–176, 1939. View at Google Scholar
  42. P. Schulze-Lefert and R. Panstruga, “A molecular evolutionary concept connecting nonhost resistance, pathogen host range, and pathogen speciation,” Trends in Plant Science, vol. 16, no. 3, pp. 117–125, 2011. View at Publisher · View at Google Scholar · View at Scopus
  43. N. Nikoh and T. Fukatsu, “Interkingdom host jumping underground: phylogenetic analysis of entomoparasitic fungi of the genus Cordyceps,” Molecular Biology and Evolution, vol. 17, no. 4, pp. 629–638, 2000. View at Publisher · View at Google Scholar · View at Scopus
  44. J. M. C. Gutteridge and B. Halliwell, “Free radicals and antioxidants in the year 2000. A historical look to the future,” Annals of the New York Academy of Sciences, vol. 899, pp. 136–147, 2000. View at Google Scholar · View at Scopus
  45. X.-T. Li, H.-C. Li, C.-B. Li, D.-Q. Dou, and M.-B. Gao, “Protective effects on mitochondria and anti-aging activity of polysaccharides from cultivated fruiting bodies of Cordyceps militaris,” American Journal of Chinese Medicine, vol. 38, no. 6, pp. 1093–1106, 2010. View at Publisher · View at Google Scholar · View at Scopus
  46. M. Chen, F. W. K. Cheung, M. H. Chan et al., “Protective roles of on Cordyceps lung fibrosis in cellular and rat models,” Journal of Ethnopharmacology, vol. 143, no. 2, pp. 448–454, 2012. View at Publisher · View at Google Scholar · View at Scopus
  47. Y. Dong, T. Jing, Q. Meng et al., “Studies on the antidiabetic activities of cordyceps militaris extract in diet-streptozotocin-induced diabetic sprague-dawley rats,” BioMed Research International, vol. 2014, Article ID 160980, 11 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  48. H.-P. Wang, C.-W. Liu, H.-W. Chang, J.-W. Tsai, Y.-Z. Sung, and L.-C. Chang, “Cordyceps sinensis protects against renal ischemia/reperfusion injury in rats,” Molecular Biology Reports, vol. 40, no. 3, pp. 2347–2355, 2013. View at Publisher · View at Google Scholar · View at Scopus
  49. B.-J. Wang, S.-J. Won, Z.-R. Yu, and C.-L. Su, “Free radical scavenging and apoptotic effects of Cordyceps sinensis fractionated by supercritical carbon dioxide,” Food and Chemical Toxicology, vol. 43, no. 4, pp. 543–552, 2005. View at Publisher · View at Google Scholar · View at Scopus
  50. W.-D. Wu, Z.-M. Hu, M.-J. Shang et al., “Cordycepin down-regulates multiple drug resistant (MDR)/HIF-1alpha through regulating AMPK/mTORC1 signaling in GBC-SD gallbladder cancer cells,” International Journal of Molecular Sciences, vol. 15, no. 7, pp. 12778–12790, 2014. View at Publisher · View at Google Scholar · View at Scopus