Protective Effects of Tao-Hong-Si-Wu Decoction on Memory Impairment and Hippocampal Damage in Animal Model of Vascular Dementia

Table 2

Effect of TSD on the activity of AChE and the contents of 5-HT, ET-1, and VEGF in hippocampus after MACO in rats.

Group	Dose (g/kg)	AChE (U/L⋅protein)	5-HT (ng/mL⋅protein)	ET-1 (ng/L⋅protein)	VEGF (ng/L⋅protein)
Sham	—	11.28 ± 0.35^**	230.76 ± 15.89	40.65 ± 5.19^**	108.99 ± 10.33^**
Model	—	12.85 ± 1.09	182.31 ± 23.25	51.06 ± 3.75	125.22 ± 9.71
TSD	18	10.12 ± 0.57^**	205.87 ± 13.53^*	43.04 ± 6.10^**	152.16 ± 10.71^**
TSD	9	11.74 ± 0.98^*	214.74 ± 16.50^**	45.87 ± 2.26^**	136.65 ± 10.85^*
TSD	4.5	12.43 ± 0.54	209.36 ± 17.20^*	49.89 ± 4.81	134.15 ± 9.94
Nimodipine	0.02	10.83 ± 0.91^**	220.99 ± 16.45^**	40.87 ± 5.08^**	147.15 ± 9.92^**

All data are mean ± S.D., . ^*, ^** compared with model group.