Extra Virgin Olive Oil Polyphenols Promote Cholesterol Efflux and Improve HDL Functionality
EVOO-PC protects macrophages against oxidation and promotes HDL-mediated cholesterol efflux. (a) THP-1-derived macrophages were loaded with [3H]-cholesterol (2 μCi/mL) for 24 h. The cells were then washed, equilibrated, and incubated for a further 24 h with 50 μg/mL of HDL-free medium, HDL, EVOO-enriched HDL (EVOO-HDL), or EVOO-PC-enriched HDL (EVOO-PC-HDL). (b) The macrophages were stressed with 0.2 mM Fe/Asc, and cholesterol efflux was assessed using 50 μg/mL of HDL. Results are expressed as the means ± SEM of at least three independent experiments. , , and .
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