Evidence-Based Complementary and Alternative Medicine

Research Article

Active Compounds of Rhubarb Root and Rhizome in Animal Model Experiments of Focal Cerebral Ischemia

Table 2

Quality characteristics of included studies.
StudyABCDEFGHIJScore
Li et al. 2005 [16]+−+−++−−?−4
Li et al. 2011 [17]+−+−−?−+?−3
Li et al. 2005 [18]+−+−−?−−?−2
Li et al. 2007 [19]+++−−?−−?−3
Li et al. 2005 [20]+++−−?−+?−4
Liu et al. 2005 [21]+−+−−?−−?−2
Li et al. 2004 [22]+++−−?−+?−4
Li et al. 2004 [23]+++−−?−−?−3
Liu et al. 2004 [24]+−+−−?−−?−2
Tan et al. 2010 [25]+−+−−+?−?−3
Wu et al. 2009 [26]+++−−+?+?−5
Wang et al. 2005 [27]+++−−?−−?−3
Li et al. 2005 [28]+++−−?−−?−3
Chen et al. 2006 [29]+++−−+?−?−4
Mei et al. 2009 [30]+−+−−+?−?−3
Chen et al. 2007 [31]+−+−−??−?−2
Song et al. 2011 [32]+++−−+?+?−5
Zhang et al. 2014 [33]+++−−+?−++6
Chen et al. 2015 [14]+−+−−+−−?−3
Guan et al. 2014 [15]+++−−+−−?−4
Note: A: publication in a peer-reviewed journal, B: statement of temperature control, C: random allocation to groups, D: blinded induction of ischemia, E: blinded assessment of outcome, F: use of anaesthetic without significant intrinsic neuroprotective activity, G: appropriate animal model (aged, diabetic, or hypertensive), H: sample size calculation, I: compliance with animal welfare regulations, and J: statement of potential conflict of interests. +: yes, −: no, and ?: unclear.