MicroRNAs’ Involvement in Osteoarthritis and the Prospects for Treatments

Figure 2

Differential expression of miRNAs between normal and osteoarthritic joints. Changes in miRNA expression can lead to the destruction of joint homeostasis, involving alterations in chondrogenesis, cartilage degradation, synovial inflammation, neurogenesis, osteoblastogenesis, and osteoclastogenesis. miR-146a is involved in cartilage degradation, synovial inflammation, neoangiogenesis, and osteoclastogenesis.