Small Molecules from Nature Targeting G-Protein Coupled Cannabinoid Receptors: Potential Leads for Drug Discovery and Development

Table 3

The chemical class of compounds showing nature derived cannabinoid ligands.

Alkaloids	Terpenes and terpenoid	Polyphenols	Fatty acid derivatives
(i) Auroglaucin; (ii) Chelerythrine; (iii) Guineensine; (iv) Bibenzyls; (v) Isoperrottetin A; (vi) Sanguinarine; (vii) γ-Sanshool; (viii) Voacamine; (ix) 3,6-Oxidovoacangine; (x) 5-Hydroxy-3,6-oxidovoacangine; (xi) Haplosamates; (xii) Desulfohaplosamates; (xiii) Piperine; (xiv) Neocosmosins; (xv) Monocillins; (xvi) Radicicol; (xvii) Yangonin	(i) Amyrin; (ii) Betulinic acid; (iii) β-Caryophyllene; (iv) Celastrol; (v) Euphol; (vi) Falcarinol; (vii) 18β-Glycyrrhetinic acid; (viii) Isoperrottetin A; (ix) Pristimerin; (x) Salvinorin A; (xi) Thujone; (xii) Yangonin; (xiii) Thujone	(i) Biochanin A; (ii) Curcumin and derivatives; (iii) Cyanidin derivatives; (iv) Desmodianones; (v) Delphinidin; (vi) (+)-Catechin derivatives; (vii) Honokiol derivatives; (viii) Peonidin; (ix) Pelargonidin; (x) Magnolol; (xi) Malvidin; (xii) Rutin; (xiii) 6-Methyltetrapterol A; (xiv) Magnolol; (xv) Miconioside; (xvi) Resveratrol	(i) Dodeca-2E,4E,8Z,10Z-tetraenoic acid isobutylamide; (ii) Dodeca-2E,4E-dienoic acid isobutylamide; (iii) 1-[(2E,4E,8Z)-Tetradecatrienoyl] piperidine; (iv) Dodeca-2E,4E-dienoic acid isobutylamide; (v) Tetradeca-2E,4E-dienoic acid isobutylamide; (vi) Tetradeca-2E,4E,8Z-trienoic acid isobutylamide; (vii) 1-[(2E,4E,8Z)-Tetradecatrienoyl] piperidine; (viii) Malyngamides; (ix) Serinolamides; (x) Sciadonic acid; (xi) Semiplenamides