Aqueous Date Flesh or Pits Extract Attenuates Liver Fibrosis via Suppression of Hepatic Stellate Cell Activation and Reduction of Inflammatory Cytokines, Transforming Growth Factor-β1 and Angiogenic Markers in Carbon Tetrachloride-Intoxicated Rats

Figure 8

Light microscopic photomicrographs of liver tissue stained H&E (scale bar = 50 μm except B = 100 μm). (a) Control liver showing normal hepatic architecture, normal hepatocytes, and blood sinusoids, while (b) represents liver section of rat receiving CCl₄ in which most of hepatocytes are degenerated and swollen with vacuolated cytoplasm and pyknotic nuclei. There is complete loss of hepatic lobule architecture. Panels (c), (d), (e), (f), and (g) represent liver sections from rats treated with coffee, DFE, DPE, and the combination of coffee + DFE and coffee + DPE, respectively, showing marked regeneration of hepatic architecture and almost all hepatocytes become normal especially rats receiving DFE alone or combinations.

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