An Integrative Thrombosis Network: Visualization and Topological Analysis

Table 1

Topological information on key proteins in the thrombosis network, ranked by degree.

Rank	Nodes	Degree	Betweenness	Closeness	Functions^a
1	Talin-RIAM complex	25	689	6.2	Platelet signaling
2	GP IIb/IIIa	23	215	6.2	Platelet signaling
3	Thrombin^b	19	3089	2.7	Multifunction
4	GPIb-IX-V^b	18	2818	2.9	Multifunction
5	p-Y419-Src	18	2866	4.8	Platelet signaling
6	Syk	16	686	4.7	Platelet signaling
7	Plasmin	15	294	1.5	Clot dissolution
8	CSK	14	151	6.3	Platelet signaling
9	vWF^b	13	542	3.4	Multifunction
10	CLFM^b	13	992	1.7	Multifunction
11	Fyn	12	133	5.6	Platelet signaling
12	GPVI-FcR	12	133	5.6	Platelet signaling
13	Lyn	12	133	5.6	Platelet signaling
14	p-Y348-Syk	12	288	6.4	Platelet signaling
15	Factor Xa	12	1032	3.5	Coagulation
16	Collagen	11	9	6.4	Platelet signaling
17	uPAR	11	145	1.5	Clot dissolution
18	Src	10	396	5.4	Platelet signaling
19	PDK1	10	21	1.0	Platelet signaling
20	AKT	10	21	1.0	Platelet signaling
21	PAI-1	10	177	1.7	Clot dissolution
22	Crk	10	502	5.5	Platelet signaling
23	p-Y397, 407, 576, 577, 861, 925-FADK1	10	414	6.4	Platelet signaling
24	TF	10	213	4.4	Coagulation
25	Thrombin-activated PAR	10	803	1.8	Platelet signaling
26	G-protein Gq	10	338	1.5	Platelet signaling
27	uPA (two-chain)	10	53	1.6	Clot dissolution

^aFunctions refer to platelet signaling, coagulation, clot dissolution, or multifunction identification summarized from Reactome.
^bThrombin, GPIb-IX-V, vWF, and CLFM are multifunctional proteins serving as two functions. The first three combining functions are in platelet signaling pathways and coagulation cascades, while CLFM is in coagulation and clot dissolution system.