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Evidence-Based Complementary and Alternative Medicine
Volume 2015 (2015), Article ID 286137, 16 pages
http://dx.doi.org/10.1155/2015/286137
Review Article

Bacoside A: Role in Cigarette Smoking Induced Changes in Brain

Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600 025, India

Received 19 October 2014; Revised 11 January 2015; Accepted 26 February 2015

Academic Editor: Andrea Zangara

Copyright © 2015 G. Vani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. World Health Organization, “Warning about the dangers of tobacco,” WHO Report on the Global Tobacco Epidemic, 2011. View at Google Scholar
  2. California Environmental Protection Agency, Proposed Identification of Environmental Tobacco Smoke as a Toxic Air Contaminant, 2005, http://repositories.cdlib.org/tc/surveys/CALEPA2005.
  3. L. Anderko, J. Braun, and P. Auinger, “Contribution of tobacco smoke exposure to learning disabilities,” Journal of Obstetric, Gynecologic, and Neonatal Nursing, vol. 39, no. 1, pp. 111–117, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. F. C. Bandiera, A. Kalaydjian Richardson, D. J. Lee, J.-P. He, and K. R. Merikangas, “Secondhand smoke exposure and mental health among children and adolescents,” Archives of Pediatrics and Adolescent Medicine, vol. 165, no. 4, pp. 332–338, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. Z. Kabir, G. N. Connolly, and H. R. Alpert, “Secondhand smoke exposure and neurobehavioral disorders among children in the United States,” Pediatrics, vol. 128, no. 2, pp. 263–270, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. S. P. Doherty, J. Grabowski, C. Hoffman, S. P. Ng, and J. T. Zelikoff, “Early life insult from cigarette smoke may be predictive of chronic diseases later in life,” Biomarkers, vol. 14, supplement 1, pp. 97–101, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. J. R. Pauly and T. A. Slotkin, “Maternal tobacco smoking, nicotine replacement and neurobehavioural development,” Acta Paediatrica, International Journal of Paediatrics, vol. 97, no. 10, pp. 1331–1337, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Berk, F. Kapczinski, A. C. Andreazza et al., “Pathways underlying neuroprogression in bipolar disorder: focus on inflammation, oxidative stress and neurotrophic factors,” Neuroscience and Biobehavioral Reviews, vol. 35, no. 3, pp. 804–817, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Moylan, M. Maes, N. R. Wray, and M. Berk, “The neuroprogressive nature of major depressive disorder: pathways to disease evolution and resistance, and therapeutic implications,” Molecular Psychiatry, vol. 18, no. 5, pp. 595–606, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. K. J. Ameringer and A. M. Leventhal, “Applying the tripartite model of anxiety and depression to cigarette smoking: an integrative review,” Nicotine and Tobacco Research, vol. 12, no. 12, pp. 1183–1194, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. O. N. Niedermaier, M. L. Smith, L. A. Beightol, Z. Zukowska-Grojec, D. S. Goldstein, and D. L. Eckberg, “Influence of cigarette smoking on human autonomic function,” Circulation, vol. 88, no. 2, pp. 562–571, 1993. View at Publisher · View at Google Scholar · View at Scopus
  12. W. A. Pryor, K. Stone, C. E. Cross, L. Machlin, and L. Packer, “Oxidants in cigarette smoke: radicals, hydrogen peroxide, peroxynitrate, and peroxynitrite,” Annals of the New York Academy of Sciences, vol. 686, pp. 12–28, 1993. View at Publisher · View at Google Scholar · View at Scopus
  13. C. J. Smith and T. H. Fischer, “Particulate and vapor phase constituents of cigarette mainstream smoke and risk of myocardial infarction,” Atherosclerosis, vol. 158, no. 2, pp. 257–267, 2001. View at Publisher · View at Google Scholar · View at Scopus
  14. W. A. Pryor, K. Stone, L.-Y. Zang, and E. Bermudez, “Fractionation of aqueous cigarette tar extracts: fractions that contain the tar radical cause DNA damage,” Chemical Research in Toxicology, vol. 11, no. 5, pp. 441–448, 1998. View at Publisher · View at Google Scholar · View at Scopus
  15. A. E. Taylor, D. C. Johnson, and H. Kazemi, “Environmental tobacco smoke and cardiovascular disease: a position paper from the council on cardiopulmonary and critical care, American Heart Association,” Circulation, vol. 86, no. 2, pp. 699–702, 1992. View at Publisher · View at Google Scholar · View at Scopus
  16. J. E. Harris, “Cigarette smoke components and disease: cigarette smoke is more than a triad of tar, nicotine, and carbon monoxide,” http://cancercontrol.cancer.gov/brp/TCRB/monographs/7/m7_5.
  17. J. D. Adams, K. J. O'Mara-Adams, and D. Hoffmann, “Toxic and carcinogenic agents in undiluted mainstream smoke and sidestream smoke of different types of cigarettes,” Carcinogenesis, vol. 8, no. 5, pp. 729–731, 1987. View at Publisher · View at Google Scholar · View at Scopus
  18. M. S. Jaakkola and J. J. K. Jaakkola, “Assessment of exposure to environmental tobacco smoke,” European Respiratory Journal, vol. 10, no. 10, pp. 2384–2397, 1997. View at Publisher · View at Google Scholar · View at Scopus
  19. L. T. Kozlowski, N. Y. Mehta, C. T. Sweeney et al., “Filter ventilation and nicotine content of tobacco in cigarettes from Canada, the United Kingdom, and the United States,” Tobacco Control, vol. 7, no. 4, pp. 369–375, 1998. View at Publisher · View at Google Scholar · View at Scopus
  20. A. K. Armitage, C. T. Dollery, C. F. George, T. H. Houseman, P. J. Lewis, and D. M. Turner, “Absorption and metabolism of nicotine from cigarettes,” British Medical Journal, vol. 4, no. 5992, pp. 313–316, 1975. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Cohen and O. George, “Animal models of nicotine exposure: relevance to second-hand smoking, electronic cigarette use, and compulsive smoking,” Frontiers in Psychiatry, vol. 4, article 41, 2013. View at Publisher · View at Google Scholar · View at Scopus
  22. M. R. Picciotto, M. Zoli, R. Rimondini et al., “Acetylcholine receptors containing the beta2 subunit are involved in the reinforcing properties of nicotine,” Nature, vol. 391, no. 6663, pp. 173–177, 1998. View at Publisher · View at Google Scholar · View at Scopus
  23. N. L. Benowitz, “Pharmacology of nicotine: addiction, smoking-induced disease, and therapeutics,” Annual Review of Pharmacology and Toxicology, vol. 49, pp. 57–71, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. A. L. Brody, “Functional brain imaging of tobacco use and dependence,” Journal of Psychiatric Research, vol. 40, no. 5, pp. 404–418, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. U.S. Department of Health and Human Services, The Health Consequences of Smoking: Nicotine Addiction, A Report of the Surgeon General No. DHHS Publication No. 88-8406, Centers for Disease Control, Office of Smoking and Health, Public Health Service, Rockville, Md, USA, 1988.
  26. I. P. Stolerman and M. J. Jarvis, “The scientific case that nicotine is addictive,” Psychopharmacology, vol. 117, no. 1, pp. 2–10, 1995. View at Publisher · View at Google Scholar · View at Scopus
  27. T. J. Abbruscato, S. P. Lopez, K. S. Mark, B. T. Hawkins, and T. P. Davis, “Nicotine and cotinine modulate cerebral microvascular permeability and protein expression of ZO-1 through nicotinic acetylcholine receptors expressed on brain endothelial cells,” Journal of Pharmaceutical Sciences, vol. 91, no. 12, pp. 2525–2538, 2002. View at Publisher · View at Google Scholar · View at Scopus
  28. J. R. Paulson, K. E. Roder, G. McAfee, D. D. Allen, C. J. Van Der Schyf, and T. J. Abbruscato, “Tobacco smoke chemicals attenuate brain-to-blood potassium transport mediated by the Na,K,2Cl-cotransporter during hypoxia-reoxygenation,” Journal of Pharmacology and Experimental Therapeutics, vol. 316, no. 1, pp. 248–254, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. D. Bernhard, C. Moser, A. Backovic, and G. Wick, “Cigarette smoke—an aging accelerator?” Experimental Gerontology, vol. 42, no. 3, pp. 160–165, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. J. A. Sonnen, E. B. Larson, S. L. Gray et al., “Free radical damage to cerebral cortex in alzheimer's disease, microvascular brain injury, and smoking,” Annals of Neurology, vol. 65, no. 2, pp. 226–229, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. P. Mazzone, W. Tierney, M. Hossain, V. Puvenna, D. Janigro, and L. Cucullo, “Pathophysiological impact of cigarette smoke exposure on the cerebrovascular system with a focus on the blood-brain barrier: expanding the awareness of smoking toxicity in an underappreciated area,” International Journal of Environmental Research and Public Health, vol. 7, no. 12, pp. 4111–4126, 2010. View at Publisher · View at Google Scholar · View at Scopus
  32. G. J. Hankey, “Smoking and risk of stroke,” Journal of Cardiovascular Risk, vol. 6, no. 4, pp. 207–211, 1999. View at Google Scholar · View at Scopus
  33. I. C. Manchev, P. P. Mineva, and D. I. Hadjiev, “Prevalence of stroke risk factors and their outcomes: a population-based longitudinal epidemiological study,” Cerebrovascular Diseases, vol. 12, no. 4, pp. 303–307, 2001. View at Publisher · View at Google Scholar · View at Scopus
  34. J. S. Gill, M. J. Shipley, S. A. Tsementzis et al., “Cigarette smoking. A risk factor for hemorrhagic and nonhemorrhagic stroke,” Archives of Internal Medicine, vol. 149, no. 9, pp. 2053–2057, 1989. View at Publisher · View at Google Scholar · View at Scopus
  35. P. Decina, G. Caracci, R. Sandik, W. Berman, S. Mukherjee, and P. Scapicchio, “Cigarette smoking and neuroleptic-induced parkinsonism,” Biological Psychiatry, vol. 28, no. 6, pp. 502–508, 1990. View at Publisher · View at Google Scholar · View at Scopus
  36. J. A. Johnsen and V. T. Miller, “Tobacco intolerance on multiple system atrophy,” Neurology, vol. 36, no. 7, pp. 986–988, 1986. View at Publisher · View at Google Scholar · View at Scopus
  37. G. D. Mellick, “CYP450, genetics and Parkinson's disease: Gene x environment interactions hold the key,” Journal of Neural Transmission. Supplementum, no. 70, pp. 159–165, 2006. View at Google Scholar · View at Scopus
  38. J. R. Barrett, “Dementia and secondhand smoke,” Environmental Health Perspectives, vol. 115, article A401, 2007. View at Google Scholar · View at Scopus
  39. R. Peters, R. Poulter, J. Warner, N. Beckett, L. Burch, and C. Bulpitt, “Smoking, dementia and cognitive decline in the elderly, a systematic review,” BMC Geriatrics, vol. 8, article 36, 2008. View at Publisher · View at Google Scholar · View at Scopus
  40. J. T. Powell, “Vascular damage from smoking: disease mechanisms at the arterial wall,” Vascular Medicine, vol. 3, no. 1, pp. 21–28, 1998. View at Publisher · View at Google Scholar · View at Scopus
  41. D. E. Barnes, T. J. Haight, K. M. Mehta, M. C. Carlson, L. H. Kuller, and I. B. Tager, “Secondhand smoke, vascular disease, and dementia incidence: findings from the cardiovascular health cognition study,” American Journal of Epidemiology, vol. 171, no. 3, pp. 292–302, 2010. View at Publisher · View at Google Scholar · View at Scopus
  42. D. J. Llewellyn, L. A. Lang, K. M. Langa, F. Naughton, and F. E. Matthews, “Exposure to secondhand smoke and cognitive impairment in non-smokers: national cross sectional study with cotinine measurement,” British Medical Journal, vol. 338, article b462, 2009. View at Publisher · View at Google Scholar · View at Scopus
  43. M. N. Sabbagh, S. L. Tyas, S. C. Emery et al., “Smoking affects the phenotype of Alzheimer disease,” Neurology, vol. 64, no. 7, pp. 1301–1303, 2005. View at Publisher · View at Google Scholar · View at Scopus
  44. A. L. Brody, M. A. Mandelkern, E. D. London et al., “Cigarette smoking saturates brain α4β2 nicotinic acetylcholine receptors,” Archives of General Psychiatry, vol. 63, no. 8, pp. 907–915, 2006. View at Publisher · View at Google Scholar · View at Scopus
  45. A. L. Brody, M. A. Mandelkern, E. D. London et al., “Effect of second hand smoke on occupancy of nicotinic acetylcholine receptors in brain,” Archives of General Psychiatry, vol. 68, no. 9, pp. 953–960, 2011. View at Publisher · View at Google Scholar · View at Scopus
  46. US Public Health Service and Office of the Surgeon General, The Health Consequences of Involuntary Exposure to Tobacco Smoke: A Report of the Surgeon General, US Department of Health and Human Services, Public Health Service, Office of the Surgeon General, Rockville, Md, USA, 2006.
  47. M. J. Jarvis, P. Hajek, M. A. H. Russell, R. J. West, and C. Feyerabend, “Nasal nicotine solution as an aid to cigarette withdrawal: a pilot clinical trial,” The British Journal of Addiction, vol. 82, no. 9, pp. 983–988, 1987. View at Publisher · View at Google Scholar · View at Scopus
  48. W. Lam, H. S. Sacks, P. Sze, and T. C. Chalmers, “Meta-analysis of randomised controlled trials of nicotine chewing-gum,” The Lancet, vol. 2, no. 8549, pp. 27–30, 1987. View at Google Scholar · View at Scopus
  49. P. Tønnesen, J. Nørregaard, K. Simonsen, and U. Säwe, “A double-blind trial of a 16-hour transdermal nicotine patch in smoking cessation,” The New England Journal of Medicine, vol. 325, no. 5, pp. 311–315, 1991. View at Publisher · View at Google Scholar · View at Scopus
  50. H. El-Bizri and P. B. S. Clarke, “Blockade of nicotinic receptor-mediated release of dopamine from striatal synaptosomes by chlorisondamine and other nicotinic antagonists administered in vitro,” British Journal of Pharmacology, vol. 111, no. 2, pp. 406–413, 1994. View at Publisher · View at Google Scholar · View at Scopus
  51. M. J. Tobin, G. Jenouri, and M. A. Sackner, “Effect of naloxone on change in breathing pattern with smoking. A hypothesis on the addictive nature of cigarette smoking,” Chest, vol. 82, no. 5, pp. 530–537, 1982. View at Publisher · View at Google Scholar · View at Scopus
  52. I. P. Stolerman, T. Goldfarb, R. Fink, and M. E. Jarvik, “Influencing cigarette smoking with nicotine antagonists,” Psychopharmacologia, vol. 28, no. 3, pp. 247–259, 1973. View at Publisher · View at Google Scholar · View at Scopus
  53. I. Berlin, S. Saïd, O. Spreux-Varoquaux et al., “A reversible monoamine oxidase a inhibitor (moclobemide) facilitates smoking cessation and abstinence in heavy, dependent smokers,” Clinical Pharmacology and Therapeutics, vol. 58, no. 4, pp. 444–452, 1995. View at Publisher · View at Google Scholar · View at Scopus
  54. N. B. Edwards, J. K. Murphy, A. D. Downs, B. J. Ackerman, and T. L. Rosenthal, “Doxepin as an adjunct to smoking cessation: a double-blind pilot study,” The American Journal of Psychiatry, vol. 146, no. 3, pp. 373–376, 1989. View at Publisher · View at Google Scholar · View at Scopus
  55. F. Gawin, M. Compton, and R. Byck, “Buspirone reduces smoking,” Archives of General Psychiatry, vol. 46, no. 3, pp. 288–289, 1989. View at Google Scholar · View at Scopus
  56. V. Nicita-Mauro, “Smoking, calcium, calcium antagonists, and aging,” Experimental Gerontology, vol. 25, no. 3-4, pp. 393–399, 1990. View at Publisher · View at Google Scholar · View at Scopus
  57. P. Pentel and D. Malin, “A vaccine for nicotine dependence: targeting the drug rather than the brain,” Respiration, vol. 69, no. 3, pp. 193–197, 2002. View at Publisher · View at Google Scholar · View at Scopus
  58. J. A. Ascher, J. O. Cole, J.-N. Colin et al., “Bupropion: a review of its mechanism of antidepressant activity,” Journal of Clinical Psychiatry, vol. 56, no. 7, pp. 395–401, 1995. View at Google Scholar · View at Scopus
  59. M. I. Damaj, F. I. Carroll, J. B. Eaton et al., “Enantioselective effects of hydroxy metabolites of bupropion on behavior and on function of monoamine transporters and nicotinic receptors,” Molecular Pharmacology, vol. 66, no. 3, pp. 675–682, 2004. View at Publisher · View at Google Scholar · View at Scopus
  60. J. W. Coe, P. R. Brooks, M. G. Vetelino et al., “Varenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking cessation,” Journal of Medicinal Chemistry, vol. 48, no. 10, pp. 3474–3477, 2005. View at Publisher · View at Google Scholar · View at Scopus
  61. A. Helen and P. L. Vijayammal, “Effect of vitamin A supplementation on cigarette smoke-induced lipid peroxidation,” Veterinary and Human Toxicology, vol. 39, no. 1, pp. 18–21, 1997. View at Google Scholar · View at Scopus
  62. N. Dilsiz, A. Olcucu, M. Cay, M. Naziroglu, and D. Cabanoglu, “Protective effects of selenium, vitamin C and vitamin E against oxidative stress of cigarette smoke in rats,” Cell Biochemistry and Function, vol. 17, no. 1, pp. 1–7, 1999. View at Publisher · View at Google Scholar
  63. A. Izzotti, R. M. Balansky, F. D'Agostini et al., “Modulation of biomarkers by chemopreventive agents in smoke-exposed rats,” Cancer Research, vol. 61, no. 6, pp. 2472–2479, 2001. View at Google Scholar · View at Scopus
  64. S. Chitra, R. Semmalar, and C. S. S. Devi, “Effect of fish oil on cigarette smoking induced dyslipidemia in rats,” Indian Journal of Pharmacology, vol. 32, no. 2, pp. 114–119, 2000. View at Google Scholar · View at Scopus
  65. S. Shishodia, P. Potdar, C. G. Gairola, and B. B. Aggarwal, “Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-κB activation through inhibition of IκBα kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1,” Carcinogenesis, vol. 24, no. 7, pp. 1269–1279, 2003. View at Publisher · View at Google Scholar · View at Scopus
  66. J. S. Shim, M. H. Kang, Y. H. Kim, J. K. Roh, C. Roberts, and I. P. Lee, “Chemopreventive effect of green tea (Camellia sinensis) among cigarette smokers,” Cancer Epidemiology Biomarkers and Prevention, vol. 4, no. 4, pp. 387–391, 1995. View at Google Scholar · View at Scopus
  67. S. Roodenrys, D. Booth, S. Bulzomi, A. Phipps, C. Micallef, and J. Smoker, “Chronic effects of Brahmi (Bacopa monnieri) on human memory,” Neuropsychopharmacology, vol. 27, no. 2, pp. 279–281, 2002. View at Publisher · View at Google Scholar · View at Scopus
  68. T. Murugesan, “Evaluation of psychopharmacological effects of Bacopa monnieri Linn Extract,” Phytomedicine, vol. 8, pp. 472–476, 2005. View at Google Scholar
  69. Y. B. Tripathi, S. Chaurasia, E. Tripathi, A. Upadhyay, and G. P. Dubey, “Bacopa monniera Linn. as an antioxidant: mechanism of action,” Indian Journal of Experimental Biology, vol. 34, no. 6, pp. 523–526, 1996. View at Google Scholar · View at Scopus
  70. S. Channa, A. Dar, M. Yaqoob, S. Anjum, Z. Sultani, and A.-U. Rahman, “Broncho-vasodilatory activity of fractions and pure constituents isolated from Bacopa monniera,” Journal of Ethnopharmacology, vol. 86, no. 1, pp. 27–35, 2003. View at Publisher · View at Google Scholar · View at Scopus
  71. A. Dar and S. Channa, “Calcium antagonistic activity of Bacopa monniera on vascular and intestinal smooth muscles of rabbit and guinea-pig,” Journal of Ethnopharmacology, vol. 66, no. 2, pp. 167–174, 1999. View at Publisher · View at Google Scholar · View at Scopus
  72. D. S. Samiulla, D. Prashanth, and A. Amit, “Mast cell stabilising activity of Bacopa monnieri,” Fitoterapia, vol. 72, no. 3, pp. 284–285, 2001. View at Publisher · View at Google Scholar · View at Scopus
  73. H. K. Singh, “Memory-enhancing and associated effects of a bacosides enriched standardised extract of Bacopa monniera,” in Advances in Natural Medicines, Nutraceuticals and Neurocognition, C. Stough and A. Scholey, Eds., pp. 251–288, CRC Press, Taylor & Francis, London, UK, 2013. View at Google Scholar
  74. S. Majumdar, A. Basu, P. Paul, M. Halder, and S. Jha, “Bacosides and Neuroprotection,” in Natural Products: Phytochemistry, Botany and Metabolism of Alkaloids, Phenolics and Terpenes, K. Ramawat and J. Merillon, Eds., pp. 3639–3660, Springer, Berlin, Germany, 2013. View at Publisher · View at Google Scholar
  75. S. Garai, S. B. Mahato, K. Ohtani, and K. Yamasaki, “Dammarane-type triterpenoid saponins from Bacopa monniera,” Phytochemistry, vol. 42, no. 3, pp. 815–820, 1996. View at Publisher · View at Google Scholar · View at Scopus
  76. A. K. Chakravarty, T. Sarkar, T. Nakane, N. Kawahara, K. Masuda, and K. Shiojima, “Bacopaside I and II: two pseudojujubogenin glycosides from Bacopa monniera,” Phytochemistry, vol. 58, no. 4, pp. 553–556, 2001. View at Publisher · View at Google Scholar · View at Scopus
  77. A. K. Chakravarty, T. Sarkar, T. Nakane, N. Kawahara, and K. Masuda, “New phenylethanoid glycosides from Bacopa monniera,” Chemical and Pharmaceutical Bulletin, vol. 50, no. 12, pp. 1616–1618, 2002. View at Publisher · View at Google Scholar · View at Scopus
  78. A. K. Chakravarty, S. Garai, K. Masuda, T. Nakane, and N. Kawahara, “Bacopasides III-V: three new triterpenoid glycosides from Bacopa monniera,” Chemical and Pharmaceutical Bulletin, vol. 51, no. 2, pp. 215–217, 2003. View at Publisher · View at Google Scholar · View at Scopus
  79. K. Anbarasi, G. Vani, K. Balakrishna, and C. S. S. Devi, “Creatine kinase isoenzyme patterns upon chronic exposure to cigarette smoke: protective effect of Bacoside A,” Vascular Pharmacology, vol. 42, no. 2, pp. 57–61, 2005. View at Publisher · View at Google Scholar · View at Scopus
  80. E. Madhukumar and P. L. Vijayammal, “Influence of cigarette smoke on cross-linking of dermal collagen,” Indian Journal of Experimental Biology, vol. 35, no. 5, pp. 483–486, 1997. View at Google Scholar · View at Scopus
  81. World Health Organization, WHO Report on the Global Tobacco Epidemic 2011. Warning about the Dangers of Tobacco, World Health Organization, Geneva, Switzerland, 2011.
  82. R. A. R. Gons, A. G. W. van Norden, K. F. de Laat et al., “Cigarette smoking is associated with reduced microstructural integrity of cerebral white matter,” Brain, vol. 134, no. 7, pp. 2116–2124, 2011. View at Publisher · View at Google Scholar · View at Scopus
  83. A. L. Brody, M. A. Mandelkern, M. E. Jarvik et al., “Differences between smokers and nonsmokers in regional gray matter volumes and densities,” Biological Psychiatry, vol. 55, no. 1, pp. 77–84, 2004. View at Publisher · View at Google Scholar · View at Scopus
  84. X. Zhang, E. A. Stein, and L. E. Hong, “Smoking and schizophrenia independently and additively reduce white matter integrity between striatum and frontal cortex,” Biological Psychiatry, vol. 68, no. 7, pp. 674–677, 2010. View at Publisher · View at Google Scholar · View at Scopus
  85. T. C. Durazzo, D. J. Meyerhoff, and S. J. Nixon, “Chronic cigarette smoking: implications for neurocognition and brain neurobiology,” International Journal of Environmental Research and Public Health, vol. 7, no. 10, pp. 3760–3790, 2010. View at Publisher · View at Google Scholar · View at Scopus
  86. R. H. Paul, S. M. Grieve, R. Niaura et al., “Chronic cigarette smoking and the microstructural integrity of white matter in healthy adults: a diffusion tensor imaging study,” Nicotine and Tobacco Research, vol. 10, no. 1, pp. 137–147, 2008. View at Publisher · View at Google Scholar · View at Scopus
  87. R. A. Wevers, P. H. P. Jansen, L. M. J. van Woerkom, W. H. Doesburg, and O. R. Hommes, “The significance of total creatine kinase activity and isozyme determinations in cerebrospinal fluid of neurological patients,” Clinica Chimica Acta, vol. 143, no. 3, pp. 193–201, 1984. View at Publisher · View at Google Scholar · View at Scopus
  88. S. V. Bhagwat, C. Vijayasarathy, H. Raza, J. Mullick, and N. G. Avadhani, “Preferential effects of nicotine and 4-(N-methyl-N-nitrosamine)-1-(3-pyridyl)-1-butanone on mitochondrial glutathione S-transferase A4-4 induction and increased oxidative stress in the rat brain,” Biochemical Pharmacology, vol. 56, no. 7, pp. 831–839, 1998. View at Publisher · View at Google Scholar · View at Scopus
  89. Z. Jin, F. Gao, T. Flagg, and X. Deng, “Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone promotes functional cooperation of Bcl2 and c-Myc through phosphorylation in regulating cell survival and proliferation,” The Journal of Biological Chemistry, vol. 279, no. 38, pp. 40209–40219, 2004. View at Publisher · View at Google Scholar · View at Scopus
  90. W. S. Griffin, “Inflammation and neurodegenerative diseases,” The American Journal of Clinical Nutrition, vol. 83, pp. 470S–474S, 2006. View at Google Scholar
  91. V. Viji and A. Helen, “Inhibition of pro-inflammatory mediators: role of Bacopa monniera (L.) Wettst,” Inflammopharmacology, vol. 19, no. 5, pp. 283–291, 2011. View at Publisher · View at Google Scholar · View at Scopus
  92. V. J. Knott, “Electroencephalographic characterization of cigarette smoking behavior,” Alcohol, vol. 24, no. 2, pp. 95–97, 2001. View at Publisher · View at Google Scholar · View at Scopus
  93. H. Shikata, H. Fukai, I. Ohya, and T. Sakaki, “Characterization of topographic EEG changes when smoking a cigarette,” Psychopharmacology, vol. 119, no. 4, pp. 361–367, 1995. View at Publisher · View at Google Scholar · View at Scopus
  94. B. B. Brown, “Frequency and phase of hippocampal theta activity in the spontaneously behaving cat,” Electroencephalography and Clinical Neurophysiology, vol. 24, no. 1, pp. 53–62, 1968. View at Publisher · View at Google Scholar · View at Scopus
  95. E. J. Nestler, “Molecular mechanisms of drug addiction,” Journal of Neuroscience, vol. 12, no. 7, pp. 2439–2450, 1992. View at Google Scholar · View at Scopus
  96. D. Bertrand, “Neurocircuitry of the nicotinic cholinergic system,” Dialogues in Clinical Neuroscience, vol. 12, no. 4, pp. 463–470, 2010. View at Google Scholar · View at Scopus
  97. K. L. Summers and E. Giacobini, “Effects of local and repeated systemic administration of (-)nicotine on extracellular levels of acetylcholine, norepinephrine, dopamine, and serotonin in rat cortex,” Neurochemical Research, vol. 20, no. 6, pp. 753–759, 1995. View at Publisher · View at Google Scholar · View at Scopus
  98. M. J. Marks, T. D. McClure-Begley, P. Whiteaker et al., “Increased nicotinic acetylcholine receptor protein underlies chronic nicotine-induced up-regulation of nicotinic agonist binding sites in mouse brain,” Journal of Pharmacology and Experimental Therapeutics, vol. 337, no. 1, pp. 187–200, 2011. View at Publisher · View at Google Scholar · View at Scopus
  99. X. Zhang, J.-Y. Tian, A.-L. Svensson, Z.-H. Gong, B. Meyerson, and A. Nordberg, “Chronic treatments with tacrine and (−)-nicotine induce different changes of nicotinic and muscarinic acetylcholine receptors in the brain of aged rat,” Journal of Neural Transmission, vol. 109, no. 3, pp. 377–392, 2002. View at Publisher · View at Google Scholar · View at Scopus
  100. P. J. Whiting and J. M. Lindstrom, “Characterization of bovine and human neuronal nicotinic acetylcholine receptors using monoclonal antibodies,” Journal of Neuroscience, vol. 8, no. 9, pp. 3395–3404, 1988. View at Google Scholar · View at Scopus
  101. M. Mamede, K. Ishizu, M. Ueda et al., “Temporal change in human nicotinic acetylcholine receptor after smoking cessation: 5IA SPECT study,” Journal of Nuclear Medicine, vol. 48, no. 11, pp. 1829–1835, 2007. View at Publisher · View at Google Scholar · View at Scopus
  102. K. P. Cosgrove, I. Esterlis, S. A. McKee et al., “Sex differences in availability of β2-nicotinic acetylcholine receptors in recently abstinent tobacco smokers,” Archives of General Psychiatry, vol. 69, no. 4, pp. 418–427, 2012. View at Publisher · View at Google Scholar · View at Scopus
  103. A. P. Govind, P. Vezina, and W. N. Green, “Nicotine-induced upregulation of nicotinic receptors: underlying mechanisms and relevance to nicotine addiction,” Biochemical Pharmacology, vol. 78, no. 7, pp. 756–765, 2009. View at Publisher · View at Google Scholar · View at Scopus
  104. A. W. Bergen, H. S. Javitz, R. Krasnow et al., “Nicotinic acetylcholine receptor variation and response to smoking cessation therapies,” Pharmacogenetics and Genomics, vol. 23, no. 2, pp. 94–103, 2013. View at Publisher · View at Google Scholar · View at Scopus
  105. W. B. Pickworth, R. M. Keenan, and J. E. Henningfield, “Nicotine: effects and mechanism,” in Handbook of Neurotoxicology, L. W. Chang and R. S. Dyer, Eds., pp. 808–818, Marcel Dekker, New York, NY, USA, 1995. View at Google Scholar
  106. A. K. Armitage and G. H. Hall, “Mode of action of intravenous nicotine in causing a fall of blood pressure in the cat,” European Journal of Pharmacology, vol. 7, no. 1, pp. 23–30, 1969. View at Publisher · View at Google Scholar · View at Scopus
  107. A. J. Dunn and S. C. Bondy, Functional Chemistry of the Brain, Spectrum Publications, Halsted Press, New York, NY, USA, 1974.
  108. J. Mathew, J. Paul, M. S. Nandhu, and C. S. Paulose, “Increased excitability and metabolism in pilocarpine induced epileptic rats: effect of Bacopa monnieri,” Fitoterapia, vol. 81, no. 6, pp. 546–551, 2010. View at Publisher · View at Google Scholar · View at Scopus
  109. J. H. Markovitz, L. Tolbert, and S. E. Winders, “Increased serotonin receptor density and platelet GPIIb/IIIa activation among smokers,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 19, no. 3, pp. 762–766, 1999. View at Publisher · View at Google Scholar · View at Scopus
  110. S. N. Mitchell, K. M. Smith, M. H. Joseph, and J. A. Gray, “Increases in tyrosine hydroxylase messenger RNA in the locus coeruleus after a single dose of nicotine are followed by time-dependent increases in enzyme activity and noradrenaline release,” Neuroscience, vol. 56, no. 4, pp. 989–997, 1993. View at Publisher · View at Google Scholar · View at Scopus
  111. W. G. Mayhan, “Acute infusion of nicotine potentiates norepinephrine-induced vasoconstriction in the hamster cheek pouch,” Journal of Laboratory and Clinical Medicine, vol. 133, no. 1, pp. 48–54, 1999. View at Publisher · View at Google Scholar · View at Scopus
  112. D. M. Rajathei, J. Preethi, H. K. Singh, and K. E. Rajan, “Molecular docking of bacosides with tryptophan hydroxylase: a model to understand the bacosides mechanism,” Natural Products and Bioprospecting, vol. 4, no. 4, pp. 251–255, 2014. View at Publisher · View at Google Scholar
  113. E. B. Ribeiro, R. L. Bettiker, M. Bogdanov, and R. J. Wurtman, “Effects of systemic nicotine on serotonin release in rat brain,” Brain Research, vol. 621, no. 2, pp. 311–318, 1993. View at Publisher · View at Google Scholar · View at Scopus
  114. M. Reuben and P. B. S. Clarke, “Nicotine-evoked [3H] 5-hydroxytryptamine release from rat striatal synaptosomes,” Neuropharmacology, vol. 39, no. 2, pp. 290–299, 2000. View at Publisher · View at Google Scholar · View at Scopus
  115. M. E. M. Benwell, D. J. K. Balfour, and J. M. Anderson, “Smoking-associated changes in the serotonergic systems of discrete regions of human brain,” Psychopharmacology, vol. 102, no. 1, pp. 68–72, 1990. View at Publisher · View at Google Scholar · View at Scopus
  116. W. Z. Potter and H. K. Manji, “Catecholamines in depression: an update,” Clinical Chemistry, vol. 40, no. 2, pp. 279–287, 1994. View at Google Scholar · View at Scopus
  117. R. F. Anda, D. F. Williamson, L. G. Escobedo, E. E. Mast, G. A. Giovino, and P. L. Remington, “Depression and the dynamics of smoking. A national perspective,” The Journal of the American Medical Association, vol. 264, no. 12, pp. 1541–1545, 1990. View at Publisher · View at Google Scholar · View at Scopus
  118. K. E. Rajan, H. K. Singh, A. Parkavi, and P. D. Charles, “Attenuation of 1-(m-chlorophenyl)-biguanide induced hippocampus-dependent memory impairment by a standardised extract of Bacopa monniera (BESEB CDRI-08),” Neurochemical Research, vol. 36, no. 11, pp. 2136–2144, 2011. View at Publisher · View at Google Scholar · View at Scopus
  119. T. G. Hastings, D. A. Lewis, and M. J. Zigmond, “Role of oxidation in the neurotoxic effects of intrastriatal dopamine injections,” Proceedings of the National Academy of Sciences of the United States of America, vol. 93, no. 5, pp. 1956–1961, 1996. View at Publisher · View at Google Scholar · View at Scopus
  120. N. Sheikh, A. Ahmad, K. B. Siripurapu, V. K. Kuchibhotla, S. Singh, and G. Palit, “Effect of Bacopa monniera on stress induced changes in plasma corticosterone and brain monoamines in rats,” Journal of Ethnopharmacology, vol. 111, no. 3, pp. 671–676, 2007. View at Publisher · View at Google Scholar · View at Scopus
  121. S. Wonnacott, “Presynaptic nicotinic ACh receptors,” Trends in Neurosciences, vol. 20, no. 2, pp. 92–98, 1997. View at Publisher · View at Google Scholar · View at Scopus
  122. H. D. Mansvelder and D. S. McGehee, “Cellular and synaptic mechanisms of nicotine addiction,” Journal of Neurobiology, vol. 53, no. 4, pp. 606–617, 2002. View at Publisher · View at Google Scholar · View at Scopus
  123. A. Lewis, J. H. Miller, and R. A. Lea, “Monoamine oxidase and tobacco dependence,” NeuroToxicology, vol. 28, no. 1, pp. 182–195, 2007. View at Publisher · View at Google Scholar · View at Scopus
  124. A.-S. Villégier, S. Lotfipour, S. C. McQuown, J. D. Belluzzi, and F. M. Leslie, “Tranylcypromine enhancement of nicotine self-administration,” Neuropharmacology, vol. 52, no. 6, pp. 1415–1425, 2007. View at Publisher · View at Google Scholar · View at Scopus
  125. J. S. Fowler, N. D. Volkow, G.-J. Wang et al., “Brain monoamine oxidase A inhibition in cigarette smokers,” Proceedings of the National Academy of Sciences of the United States of America, vol. 93, no. 24, pp. 14065–14069, 1996. View at Publisher · View at Google Scholar · View at Scopus
  126. J. S. Fowler, N. D. Volkow, G.-J. Wang et al., “Inhibition of monoamine oxidase B in the brains of smokers,” Nature, vol. 379, no. 6567, pp. 733–736, 1996. View at Publisher · View at Google Scholar · View at Scopus
  127. F. Rendu, K. Peoc'h, I. Berlin, D. Thomas, and J.-M. Launay, “Smoking related diseases: the central role of monoamine oxidase,” International Journal of Environmental Research and Public Health, vol. 8, no. 1, pp. 136–147, 2011. View at Publisher · View at Google Scholar · View at Scopus
  128. R. Singh, R. Ramakrishna, M. Bhateria, and R. S. Bhatta, “In vitro evaluation of Bacopa monniera extract and individual constituents on human recombinant monoamine oxidase enzymes,” Phytotherapy Research, vol. 28, no. 9, pp. 1419–1422, 2014. View at Publisher · View at Google Scholar · View at Scopus
  129. C. L. Law, P. C. L. Wong, and W. F. Fong, “Effects of polyamines on the uptake of neurotransmitters by rat brain synaptosomes,” Journal of Neurochemistry, vol. 42, no. 3, pp. 870–872, 1984. View at Publisher · View at Google Scholar · View at Scopus
  130. T. A. Slotkin, B. D. Freibaum, C. A. Tate et al., “Long-lasting CNS effects of a short-term chemical knockout of ornithine decarboxylase during development: nicotinic cholinergic receptor upregulation and subtle macromolecular changes in adulthood,” Brain Research, vol. 981, no. 1-2, pp. 118–125, 2003. View at Publisher · View at Google Scholar · View at Scopus
  131. L. J. Reed and J. de Belleroche, “Induction of ornithine decarboxylase in cerebral cortex by excitotoxin lesion of nucleus basalis: association with postsynaptic responsiveness and N-methyl-D-aspartate receptor activation,” Journal of Neurochemistry, vol. 55, no. 3, pp. 780–787, 1990. View at Publisher · View at Google Scholar · View at Scopus
  132. J. A. Lukkarinen, R. A. Kauppinen, O. H. Gröhn et al., “Neuroprotective role of ornithine decarboxylase activation in transient focal cerebral ischaemia: a study using ornithine decarboxylase-overexpressing transgenic rats,” European Journal of Neuroscience, vol. 10, no. 6, pp. 2046–2055, 1998. View at Publisher · View at Google Scholar · View at Scopus
  133. G. A. Dienel and N. F. Cruz, “Induction of brain ornithine decarboxylase during recovery from metabolic, mechanical, thermal, or chemical injury,” Journal of Neurochemistry, vol. 42, no. 4, pp. 1053–1061, 1984. View at Publisher · View at Google Scholar · View at Scopus
  134. F. Facchinetti, M. Virgili, P. Migani, O. Barnabei, and A. Contestabile, “Induction of brain ornithine decarboxylase after systemic or intrastriatal administration of kainic acid,” Neuroscience Letters, vol. 140, no. 1, pp. 59–62, 1992. View at Publisher · View at Google Scholar · View at Scopus
  135. S. Ramasamy, L. V. Kiew, and L. Y. Chung, “Inhibition of human cytochrome P450 enzymes by Bacopa monnieri standardized extract and constituents,” Molecules, vol. 19, no. 2, pp. 2588–2601, 2014. View at Publisher · View at Google Scholar · View at Scopus
  136. D. Kar Chowdhuri, D. Parmar, P. Kakkar, R. Shukla, P. K. Seth, and R. C. Srimal, “Antistress effects of bacosides of Bacopa monnieri: modulation of Hsp70 expression, superoxide dismutase and cytochrome P450 activity in rat brain,” Phytotherapy Research, vol. 16, no. 7, pp. 639–645, 2002. View at Publisher · View at Google Scholar · View at Scopus
  137. S. Zevin and N. L. Benowitz, “Drug interactions with tobacco smoking. An update,” Clinical Pharmacokinetics, vol. 36, no. 6, pp. 425–438, 1999. View at Publisher · View at Google Scholar · View at Scopus
  138. N. L. Benowitz and P. Jacob III, “Effects of cigarette smoking and carbon monoxide on nicotine and cotinine metabolism,” Clinical Pharmacology and Therapeutics, vol. 67, no. 6, pp. 653–659, 2000. View at Publisher · View at Google Scholar · View at Scopus
  139. N. L. Benowitz, F. Kuyt, and P. Jacob III, “Circadian blood nicotine concentrations during cigarette smoking,” Clinical Pharmacology and Therapeutics, vol. 32, no. 6, pp. 758–764, 1982. View at Publisher · View at Google Scholar · View at Scopus
  140. S. Zevin, P. Jacob III, and N. Benowitz, “Cotinine effects on nicotine metabolism,” Clinical Pharmacology and Therapeutics, vol. 61, no. 6, pp. 649–654, 1997. View at Publisher · View at Google Scholar · View at Scopus
  141. T. T. Denton, X. Zhang, and J. R. Cashman, “Nicotine-related alkaloids and metabolites as inhibitors of human cytochrome P-450 2A6,” Biochemical Pharmacology, vol. 67, no. 4, pp. 751–756, 2004. View at Publisher · View at Google Scholar · View at Scopus
  142. K. A. Schoedel, E. M. Sellers, R. Palmour, and R. F. Tyndale, “Down-regulation of hepatic nicotine metabolism and a CYP2A6-like enzyme in African green monkeys after long-term nicotine administration,” Molecular Pharmacology, vol. 63, no. 1, pp. 96–104, 2003. View at Publisher · View at Google Scholar · View at Scopus
  143. H. L. Liston, J. S. Markowitz, and C. L. DeVane, “Drug glucuronidation in clinical psychopharmacology,” Journal of Clinical Psychopharmacology, vol. 21, no. 5, pp. 500–515, 2001. View at Publisher · View at Google Scholar · View at Scopus
  144. K. Anbarasi, Neuroprotective role of Bacoside A in rats exposed to cigarette smoke [Ph.D. thesis], University of Madras, Chennai, India, 2005.
  145. D. Rai, G. Bhatia, G. Palit, R. Pal, S. Singh, and H. K. Singh, “Adaptogenic effect of Bacopa monniera (Brahmi),” Pharmacology Biochemistry and Behavior, vol. 75, no. 4, pp. 823–830, 2003. View at Publisher · View at Google Scholar · View at Scopus
  146. N. Delibas, R. Ozcankaya, I. Altuntas, and R. Sutcu, “Effect of cigarette smoke on lipid peroxidation, antioxidant enzymes and NMDA receptor subunits 2A and 2B concentration in rat hippocampus,” Cell Biochemistry and Function, vol. 21, no. 1, pp. 69–73, 2003. View at Publisher · View at Google Scholar · View at Scopus
  147. K. Anbarasi, G. Vani, K. Balakrishna, and C. S. S. Devi, “Effect of bacoside A on brain antioxidant status in cigarette smoke exposed rats,” Life Sciences, vol. 78, no. 12, pp. 1378–1384, 2006. View at Publisher · View at Google Scholar · View at Scopus
  148. J. Hilbert and V. Mohsenin, “Adaptation of lung antioxidants to cigarette smoking in humans,” Chest, vol. 110, no. 4, pp. 916–920, 1996. View at Publisher · View at Google Scholar · View at Scopus
  149. S. A. Hulea, R. Olinescu, S. Nita, D. Crocnan, and F. A. Kummerow, “Cigarette smoking causes biochemical changes in blood that are suggestive of oxidative stress: a case-control study,” Journal of Environmental Pathology, Toxicology and Oncology, vol. 14, no. 3-4, pp. 173–180, 1995. View at Google Scholar · View at Scopus
  150. B. Frei, T. M. Forte, B. N. Ames, and C. E. Cross, “Gas phase oxidants of cigarette smoke induce lipid peroxidation and changes in lipoprotein properties in human blood plasma,” Biochemical Journal, vol. 277, no. 1, pp. 133–138, 1991. View at Google Scholar · View at Scopus
  151. G. R. Duthie and J. R. Arthur, “Cigarette smoking as an inducer of oxidative stress,” in Exercise and Oxygen Toxicity, K. S. Chandan, L. Packer, and H. Osmo, Eds., pp. 297–317, Elsevier Science, New York, NY, USA, 1994. View at Google Scholar
  152. E. Méndez-Álvarez, R. Soto-Otero, I. Sánchez-Sellero, and M. L.-R. Lamas, “In vitro inhibition of catalase activity by cigarette smoke: Relevance for oxidative stress,” Journal of Applied Toxicology, vol. 18, no. 6, pp. 443–448, 1998. View at Publisher · View at Google Scholar · View at Scopus
  153. H. A. Nadiger, C. A. Mathew, and B. Sadasivudu, “Serum malanodialdehyde (TBA reactive substance) levels in cigarette smokers,” Atherosclerosis, vol. 64, no. 1, pp. 71–73, 1987. View at Publisher · View at Google Scholar · View at Scopus
  154. G. J. Handelman, L. Packer, and C. E. Cross, “Destruction of tocopherols, carotenoids, and retinol in human plasma by cigarette smoke,” The American Journal of Clinical Nutrition, vol. 63, no. 4, pp. 559–565, 1996. View at Google Scholar · View at Scopus
  155. C. E. Cross, A. van der Vliet, and J. P. Eiserich, “Cigarette smokers and oxidant stress: a continuing mystery,” The American journal of clinical nutrition, vol. 67, no. 2, pp. 184–185, 1998. View at Google Scholar · View at Scopus
  156. D. Lapenna, S. de Gioia, A. Mezzetti et al., “Cigarette smoke, ferritin, and lipid peroxidation,” American Journal of Respiratory and Critical Care Medicine, vol. 151, no. 2, pp. 431–435, 1995. View at Publisher · View at Google Scholar · View at Scopus
  157. A. M. Preston, “Cigarette smoking-nutritional implications,” Progress in Food and Nutrition Science, vol. 15, no. 4, pp. 183–217, 1991. View at Google Scholar · View at Scopus
  158. M.-J. Hosseini, P. Naserzadeh, A. Salimi, and J. Pourahmad, “Toxicity of cigarette smoke on isolated lung, heart, and brain mitochondria: induction of oxidative stress and cytochrome c release,” Toxicological and Environmental Chemistry, vol. 95, no. 9, pp. 1624–1637, 2013. View at Publisher · View at Google Scholar · View at Scopus
  159. Y.-M. Yang and G.-T. Liu, “Injury of mouse brain mitochondria induced by cigarette smoke extract and effect of vitamin C on it in vitro,” Biomedical and Environmental Sciences, vol. 16, no. 3, pp. 256–266, 2003. View at Google Scholar · View at Scopus
  160. K. Anbarasi, G. Vani, and C. S. S. Devi, “Protective effect of bacoside A on cigarette smoking-induced brain mitochondrial dysfunction in rats,” Journal of Environmental Pathology, Toxicology and Oncology, vol. 24, no. 3, pp. 225–234, 2005. View at Publisher · View at Google Scholar · View at Scopus
  161. A. E. Speck, D. Fraga, P. Soares et al., “Cigarette smoke inhibits brain mitochondrial adaptations of exercised mice,” Neurochemical Research, vol. 36, no. 6, pp. 1056–1061, 2011. View at Publisher · View at Google Scholar · View at Scopus
  162. J. R. Pauly and T. A. Slotkin, “Maternal tobacco smoking, nicotine replacement and neurobehavioural development,” Acta Paediatrica, vol. 97, no. 10, pp. 1331–1337, 2008. View at Publisher · View at Google Scholar · View at Scopus
  163. M. Steinlin, “Cerebellar disorders in childhood: cognitive problems,” Cerebellum, vol. 7, no. 4, pp. 607–610, 2008. View at Publisher · View at Google Scholar · View at Scopus
  164. K. Anbarasi, G. Vani, K. Balakrishna, and C. S. Devi, “Effect of bacoside A on membrane-bound ATPases in the brain of rats exposed to cigarette smoke,” Journal of Biochemical and Molecular Toxicology, vol. 19, no. 1, pp. 59–65, 2005. View at Publisher · View at Google Scholar · View at Scopus
  165. H. Rauchova, J. Ledvinkova, M. Kalous, and Z. Drahota, “The effect of lipid peroxidation on the activity of various membrane-bound ATPases in rat kidney,” International Journal of Biochemistry and Cell Biology, vol. 27, no. 3, pp. 251–255, 1995. View at Publisher · View at Google Scholar · View at Scopus
  166. J. H. Sisson, D. J. Tuma, and S. I. Rennard, “Acetaldehyde-mediated cilia dysfunction in bovine bronchial epithelial cells,” The American Journal of Physiology—Lung Cellular and Molecular Physiology, vol. 260, no. 2, part 1, pp. L29–L36, 1991. View at Google Scholar · View at Scopus
  167. G. J. Lees, “Inhibition of sodium-potassium-ATPase: a potentially ubiquitous mechanism contributing to central nervous system neuropathology,” Brain Research Reviews, vol. 16, no. 3, pp. 283–300, 1991. View at Publisher · View at Google Scholar · View at Scopus
  168. A. Y. Xiao, L. Wei, S. Xia, S. Rothman, and S. P. Yu, “Ionic mechanism of ouabain-induced concurrent apoptosis and necrosis in individual cultured cortical neurons,” Journal of Neuroscience, vol. 22, no. 4, pp. 1350–1362, 2002. View at Google Scholar · View at Scopus
  169. A. K. Singh, “Early developmental changes in intracellular Ca2+ stores in rat brain,” Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology, vol. 123, no. 2, pp. 163–172, 1999. View at Publisher · View at Google Scholar · View at Scopus
  170. A. Zaidi and M. L. Michaelis, “Effects of reactive oxygen species on brain synaptic plasma membrane Ca2+-ATPase,” Free Radical Biology and Medicine, vol. 27, no. 7-8, pp. 810–821, 1999. View at Publisher · View at Google Scholar · View at Scopus
  171. M. Brownlee, “Advanced protein glycosylatlon in diabetes and aging,” Annual Review of Medicine, vol. 46, pp. 223–234, 1995. View at Publisher · View at Google Scholar · View at Scopus
  172. M. Brownlee, “Negative consequences of glycation,” Metabolism, vol. 49, no. 2, pp. 9–13, 2000. View at Publisher · View at Google Scholar · View at Scopus
  173. P. K. Janicki, J. L. Horn, G. Singh, W. T. Franks, and J. J. Franks, “Diminished brain synaptic plasma membrane Ca2+-ATPase activity in rats with streptozocin-induced diabetes: association with reduced anesthetic requirements,” Life Sciences, vol. 55, no. 18, pp. PL359–PL364, 1994. View at Publisher · View at Google Scholar · View at Scopus
  174. T. C. Squier and D. J. Bigelow, “Protein oxidation and age-dependent alterations in calcium homeostasis,” Frontiers in Bioscience, vol. 5, pp. D504–D526, 2000. View at Publisher · View at Google Scholar · View at Scopus
  175. N. Nedeljkovic, G. Nikezic, A. Horvat, S. Pekovic, M. Stojiljkovic, and J. V. Martinovic, “Properties of Mg(2+)-ATPase rat brain synaptic plasma membranes,” General Physiology and Biophysics, vol. 17, pp. 3–13, 1998. View at Google Scholar
  176. A. Grochowalska and R. Bernat, “Adaptacja aktywności ATP-az synaptosomów różnych obszarów mózgu w hipoksji, modyfikowanej wpływem adrenergicznym i gabaergicznym (Adaptation of ATP-ase activity in synaptosomes of various cerebral regions in hypoxia, modified by adrenergic and gabaergic influences),” Nowiny Lekarskie, vol. 66, no. 4, pp. 397–412, 1997. View at Google Scholar
  177. R. Vink, T. K. McIntosh, and A. I. Faden, “Magnesium in central nervous system,” in Neuroscience Year, G. Adelman, Ed., Supplement 1 to the Encyclopedia of Neuroscience, pp. 93–94, Birkhäuser, Boston, Mass, USA, 1989. View at Google Scholar
  178. H. Haga, “Effects of dietary magnesium supplementation on diurnal variations of blood pressure and plasma Na+, K+-ATPase activity in essential hypertension,” Japanese Heart Journal, vol. 33, no. 6, pp. 785–800, 1992. View at Publisher · View at Google Scholar · View at Scopus
  179. A. Rajpurkar, Y. Jiang, C. B. Dhabuwala, J. C. Dunbar, and H. Li, “Cigarette smoking induces apoptosis in rat testis,” Journal of Environmental Pathology, Toxicology and Oncology, vol. 21, no. 3, pp. 243–248, 2002. View at Google Scholar · View at Scopus
  180. A. J. Blaschke, J. A. Weiner, and J. Chun, “Programmed cell death is a universal feature of embryonic and postnatal neuroproliferative regions throughout the central nervous system,” The Journal of Comparative Neurology, vol. 396, no. 1, pp. 39–50, 1998. View at Publisher · View at Google Scholar
  181. T. S. Roy, J. E. Andrews, F. J. Seidler, and T. A. Slotkin, “Nicotine evokes cell death in embryonic rat brain during neurulation,” Journal of Pharmacology and Experimental Therapeutics, vol. 287, no. 3, pp. 1136–1144, 1998. View at Google Scholar · View at Scopus
  182. R. Garrido, K. King-Pospisil, K. W. Son, B. Hennig, and M. Toborek, “Nicotine upregulates nerve growth factor expression and prevents apoptosis of cultured spinal cord neurons,” Neuroscience Research, vol. 47, no. 3, pp. 349–355, 2003. View at Publisher · View at Google Scholar · View at Scopus
  183. K. Anbarasi, G. Kathirvel, G. Vani, G. Jayaraman, and C. S. Shyamala Devi, “Cigarette smoking induces heat shock protein 70 kDa expression and apoptosis in rat brain: modulation by bacoside A,” Neuroscience, vol. 138, no. 4, pp. 1127–1135, 2006. View at Publisher · View at Google Scholar · View at Scopus
  184. S. Dwivedi, R. Nagarajan, K. Hanif, H. H. Siddiqui, C. Nath, and R. Shukla, “Standardized extract of Bacopa monniera attenuates okadaic acid induced memory dysfunction in rats: effect on Nrf2 pathway,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 294501, 18 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  185. R. D. Shytle, A. A. Silver, R. J. Lukas, M. B. Newman, D. V. Sheehan, and P. R. Sanberg, “Nicotinic acetylcholine receptors as targets for antidepressants,” Molecular Psychiatry, vol. 7, no. 6, pp. 525–535, 2002. View at Publisher · View at Google Scholar · View at Scopus
  186. M. B. Newman, G. W. Arendash, R. D. Shytle, P. C. Bickford, T. Tighe, and P. R. Sanberg, “Nicotine's oxidative and antioxidant properties in CNS,” Life Sciences, vol. 71, no. 24, pp. 2807–2820, 2002. View at Publisher · View at Google Scholar · View at Scopus
  187. G. N. Neigh, K. Karelina, E. R. Glasper et al., “Anxiety after cardiac arrest/cardiopulmonary resuscitation: exacerbated by stress and prevented by minocycline,” Stroke, vol. 40, no. 11, pp. 3601–3607, 2009. View at Publisher · View at Google Scholar · View at Scopus
  188. P. Casolini, A. Catalani, A. R. Zuena, and L. Angelucci, “Inhibition of COX-2 reduces the age-dependent increase of hippocampal inflammatory markers, corticosterone secretion, and behavioral impairments in the rat,” Journal of Neuroscience Research, vol. 68, no. 3, pp. 337–343, 2002. View at Publisher · View at Google Scholar · View at Scopus