Beneficial Effects of Qili Qiangxin Capsule on Lung Structural Remodeling in Ischemic Heart Failure via TGF-<svg  xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg"   style="vertical-align:-4.268501pt" id="M1" height="16.5463pt" version="1.1" viewBox="-0.0657574 -12.2778 10.5522 16.5463" width="10.5522pt"><g transform="matrix(.017,0,0,-0.017,0,0)"><path id="g5-224" d="M584 573C584 646 528 703 441 703C387 703 327 679 274 632C202 568 166 493 132 302L57 -122C43 -201 35 -214 21 -227L25 -246C54 -244 122 -236 156 -203C168 -191 175 -162 195 -40L261 369C291 556 318 652 391 652C431 652 465 620 465 543C465 497 449 456 408 422C395 411 364 405 340 403L309 336C386 319 447 279 447 188C447 105 419 50 329 50C290 50 253 63 226 77L216 55C218 23 252 -16 286 -16C324 -16 369 3 419 31C488 69 575 149 575 238C575 325 516 369 437 400C516 443 584 486 584 573Z" /><glyph.data ascent="3481" descent="-2878" horiz-adv-x="605" vert-adv-y="605" /></g></svg>1/Smad3 Pathway

<div>Effects of qili qiangxin (QL) on lung vascular muscularization in rats with chronic heart failure (CHF). Histological lung section with hematoxylin and eosin staining and quantitative analysis of the distribution of nonmuscular, partially muscular, fully muscularized small arteries (<svg height="15.4345pt" id="M52" style="vertical-align:-3.834pt" version="1.1" viewbox="-0.0498162 -11.6005 51.7222 15.4345" width="51.7222pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M677 3L350 556H348L21 3L23 1H675L677 3Z" id="g51-160"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="699" vert-adv-y="699"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,6.883,.966)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 304C289 304 265 311 250 317L295 559C302 594 310 606 323 611C335 616 350 619 367 619C455 619 508 573 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transform="matrix(.013,0,0,-0.013,39.033,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z" id="g113-49"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="480" vert-adv-y="480"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,45.273,0)"><path d="M153 550H386L412 615L406 623H120L82 318C104 327 142 338 184 338C294 338 347 275 347 187C347 112 305 39 221 39C160 39 119 71 97 89C88 97 80 96 71 90C59 80 50 67 49 57C48 45 52 36 66 23C80 9 123 -12 169 -12C221 -11 288 15 342 59C403 109 431 165 431 225C431 308 366 395 238 395C212 395 165 379 127 364L153 550Z" id="g113-54"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="480" vert-adv-y="480"></glyph.data></g></svg> versus the Sham group, <svg height="13.9365pt" id="M53" style="vertical-align:-3.834pt" version="1.1" viewbox="-0.0498162 -10.1025 50.9184 13.9365" 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23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 304C289 304 265 311 250 317L295 559C302 594 310 606 323 611C335 616 350 619 367 619C455 619 508 573 508 481Z" id="g113-81"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="617" vert-adv-y="617"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,17.762,0)"><path d="M512 -3V55L134 254V256L512 456V514L75 281V230L512 -3Z" id="g117-91"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="587" vert-adv-y="587"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,29.025,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z" id="g113-49"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="480" vert-adv-y="480"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,35.265,0)"><path d="M113 -12C146 -12 170 11 170 46C170 78 146 103 114 103S58 78 58 46C58 11 82 -12 113 -12Z" id="g113-47"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="228" vert-adv-y="228"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,38.229,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z" id="g113-49"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="480" vert-adv-y="480"></glyph.data></g><g transform="matrix(.013,0,0,-0.013,44.469,0)"><path d="M153 550H386L412 615L406 623H120L82 318C104 327 142 338 184 338C294 338 347 275 347 187C347 112 305 39 221 39C160 39 119 71 97 89C88 97 80 96 71 90C59 80 50 67 49 57C48 45 52 36 66 23C80 9 123 -12 169 -12C221 -11 288 15 342 59C403 109 431 165 431 225C431 308 366 395 238 395C212 395 165 379 127 364L153 550Z" id="g113-54"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="480" vert-adv-y="480"></glyph.data></g></svg> versus the CHF group).</div>

Evidence-Based Complementary and Alternative Medicine

fig4

Figure 4

Figure 4: Beneficial Effects of Qili Qiangxin Capsule on Lung Structural Remodeling in Ischemic Heart Failure via TGF-<svg  xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg"   style="vertical-align:-4.268501pt" id="M1" height="16.5463pt" version="1.1" viewBox="-0.0657574 -12.2778 10.5522 16.5463" width="10.5522pt"><g transform="matrix(.017,0,0,-0.017,0,0)"><path id="g5-224" d="M584 573C584 646 528 703 441 703C387 703 327 679 274 632C202 568 166 493 132 302L57 -122C43 -201 35 -214 21 -227L25 -246C54 -244 122 -236 156 -203C168 -191 175 -162 195 -40L261 369C291 556 318 652 391 652C431 652 465 620 465 543C465 497 449 456 408 422C395 411 364 405 340 403L309 336C386 319 447 279 447 188C447 105 419 50 329 50C290 50 253 63 226 77L216 55C218 23 252 -16 286 -16C324 -16 369 3 419 31C488 69 575 149 575 238C575 325 516 369 437 400C516 443 584 486 584 573Z" /><glyph.data ascent="3481" descent="-2878" horiz-adv-x="605" vert-adv-y="605" /></g></svg>1/Smad3 Pathway 

Evidence-Based Complementary and Alternative Medicine

Beneficial Effects of Qili Qiangxin Capsule on Lung Structural Remodeling in Ischemic Heart Failure via TGF-1/Smad3 Pathway

Figure 4