Huqi San-Evoked Rat Colonic Anion Secretion through Increasing CFTR Expression

Figure 5

Effects of forskolin-induced responses in model rat. The baseline indicates the anion secretion of distal colon in control group and model group (a). The colonic transepithelial resistance has no significant attenuation in the model group (b). Summary of the effects of forskolin- (10 μmol/L, apical) induced Δ in model rats distal colon comparison of normal rats (c). Representative recording with arrows indicating the time for the apical application of glibenclamide (1 mm/L) or basolateral application of bumetanide (100 μmol/L), respectively, and pretreatment with forskolin (10 μmol/L, apical) (d). Unpaired -test was used. Values are represented as mean ± SEM; .

(a)

(b)

(c)

(d)