Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2015 (2015), Article ID 312072, 8 pages
http://dx.doi.org/10.1155/2015/312072
Research Article

Prophylactic Treatment with Adlay Bran Extract Reduces the Risk of Severe Acute Radiation Dermatitis: A Prospective, Randomized, Double-Blind Study

1Department of Radiation Oncology, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
2Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
3Department of General Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
4National Sun Yat-Sen University-Kaohsiung Medical University Joint Research Center, Kaohsiung 807, Taiwan
5Division of Gastrointestinal and General Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
6Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan
7Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
8Translational Research Center, Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
9Institute of Occupational Safety and Health, Department of Public Health, Kaohsiung Medical University, Kaohsiung 807, Taiwan
10Department of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
11Department of Dermatology, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan

Received 23 June 2015; Accepted 2 September 2015

Academic Editor: Janelle Wheat

Copyright © 2015 Chih-Jen Huang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. L. Ryan, “Ionizing radiation: the good, the bad, and the ugly,” The Journal of Investigative Dermatology, vol. 132, no. 3, part 2, pp. 985–993, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. S. R. Hymes, E. A. Strom, and C. Fife, “Radiation dermatitis: clinical presentation, pathophysiology, and treatment 2006,” Journal of the American Academy of Dermatology, vol. 54, no. 1, pp. 28–46, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. J. L. Harper, L. E. Franklin, J. M. Jenrette, and E. G. Aguero, “Skin toxicity during breast irradiation: pathophysiology and management,” Southern Medical Journal, vol. 97, no. 10, pp. 989–993, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. K. R. Brown and E. Rzucidlo, “Acute and chronic radiation injury,” Journal of Vascular Surgery, vol. 53, no. 1, supplement, pp. 15S–21S, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. N. Salvo, E. Barnes, J. van Draanen et al., “Prophylaxis and management of acute radiation-induced skin reactions: a systematic review of the literature,” Current Oncology, vol. 17, no. 4, pp. 94–112, 2010. View at Google Scholar · View at Scopus
  6. A. Bolderston, N. S. Lloyd, R. K. Wong, L. Holden, and L. Robb-Blenderman, “The prevention and management of acute skin reactions related to radiation therapy: a systematic review and practice guideline,” Supportive Care in Cancer, vol. 14, no. 8, pp. 802–817, 2006. View at Google Scholar
  7. C.-P. Chung, H.-Y. Hsu, D.-W. Huang et al., “Ethyl acetate fraction of adlay bran ethanolic extract inhibits oncogene expression and suppresses DMH-induced preneoplastic lesions of the colon in F344 rats through an anti-inflammatory pathway,” Journal of Agricultural and Food Chemistry, vol. 58, no. 13, pp. 7616–7623, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. D.-W. Huang, C.-H. Wu, C.-K. Shih et al., “Application of the solvent extraction technique to investigation of the anti-inflammatory activity of adlay bran,” Food Chemistry, vol. 145, pp. 445–453, 2014. View at Publisher · View at Google Scholar · View at Scopus
  9. H.-J. Chen, C.-P. Chung, W. Chiang, and Y.-L. Lin, “Anti-inflammatory effects and chemical study of a flavonoid-enriched fraction from adlay bran,” Food Chemistry, vol. 126, no. 4, pp. 1741–1748, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. C.-P. Chung, S.-M. Hsia, M.-Y. Lee et al., “Gastroprotective activities of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) on the growth of the stomach cancer AGS cell line and indomethacin-induced gastric ulcers,” Journal of Agricultural and Food Chemistry, vol. 59, no. 11, pp. 6025–6033, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. H.-T. Yao, J.-H. Lin, M.-T. Chiang, W. Chiang, M.-N. Luo, and C.-K. Lii, “Suppressive effect of the ethanolic extract of adlay bran on cytochrome P-450 enzymes in rat liver and lungs,” Journal of Agricultural and Food Chemistry, vol. 59, no. 8, pp. 4306–4314, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Zhao, D. Zhu, D. Sun-Waterhouse et al., “In vitro and in vivo studies on adlay-derived seed extracts: phenolic profiles, antioxidant activities, serum uric acid suppression, and xanthine oxidase inhibitory effects,” Journal of Agricultural and Food Chemistry, vol. 62, no. 31, pp. 7771–7778, 2014. View at Publisher · View at Google Scholar · View at Scopus
  13. C.-P. Chung, C.-Y. Hsu, J.-H. Lin, Y.-H. Kuo, W. Chiang, and Y.-L. Lin, “Antiproliferative lactams and spiroenone from adlay bran in human breast cancer cell lines,” Journal of Agricultural and Food Chemistry, vol. 59, no. 4, pp. 1185–1194, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. M.-Y. Lee, H.-Y. Lin, F. Cheng, W. Chiang, and Y.-H. Kuo, “Isolation and characterization of new lactam compounds that inhibit lung and colon cancer cells from adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) bran,” Food and Chemical Toxicology, vol. 46, no. 6, pp. 1933–1939, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. International Commission on Radiation Units and Measurements (ICRU), “Prescribing, recording, and reporting photon beam therapy,” ICRU Report 50, ICRU Publications, Bethesda, Md, USA, 1993. View at Google Scholar
  16. International Commission on Radiation Units and Measurements (ICRU), ICRU Report 62: Prescribing, Recording and Reporting Photon Beam Therapy (Supplement to ICRU Report 50), ICRU Publications, Bethesda, Md, USA, 1999.
  17. J. C. Dumville, S. Hahn, J. N. V. Miles, and D. J. Torgerson, “The use of unequal randomisation ratios in clinical trials: a review,” Contemporary Clinical Trials, vol. 27, no. 1, pp. 1–12, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. J. B. Schnur, S. C. Ouellette, T. A. Dilorenzo, S. Green, and G. H. Montgomery, “A qualitative analysis of acute skin toxicity among breast cancer radiotherapy patients,” Psycho-Oncology, vol. 20, no. 3, pp. 260–268, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. N. S. Bese, J. Hendry, and B. Jeremic, “Effects of prolongation of overall treatment time due to unplanned interruptions during radiotherapy of different tumor sites and practical methods for compensation,” International Journal of Radiation Oncology, Biology, Physics, vol. 68, no. 3, pp. 654–661, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. J. W. Denham and M. Hauer-Jensen, “The radiotherapeutic injury—a complex ‘wound’,” Radiotherapy and Oncology, vol. 63, no. 2, pp. 129–145, 2002. View at Publisher · View at Google Scholar · View at Scopus
  21. K. Müller and V. Meineke, “Radiation-induced alterations in cytokine production by skin cells,” Experimental Hematology, vol. 35, supplement 1, no. 4, pp. 96–104, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. J. D. Cox, J. Stetz, and T. F. Pajak, “Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC),” International Journal of Radiation Oncology, Biology, Physics, vol. 31, no. 5, pp. 1341–1346, 1995. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Dische, “The uniform reporting of treatment-related morbidity,” Seminars in Radiation Oncology, vol. 4, no. 2, pp. 112–118, 1994. View at Publisher · View at Google Scholar · View at Scopus
  24. A. Trotti, A. D. Colevas, A. Setser et al., “CTCAE v3.0: development of a comprehensive grading system for the adverse effects of cancer treatment,” Seminars in Radiation Oncology, vol. 13, no. 3, pp. 176–181, 2003. View at Publisher · View at Google Scholar · View at Scopus
  25. E. López, M. I. Núñez, M. R. Guerrero et al., “Breast cancer acute radiotherapy morbidity evaluated by different scoring systems,” Breast Cancer Research and Treatment, vol. 73, no. 2, pp. 127–134, 2002. View at Publisher · View at Google Scholar · View at Scopus
  26. D. Feight, T. Baney, S. Bruce, and M. McQuestion, “Putting evidence into practice: evidence-based interventions for radiation dermatitis,” Clinical Journal of Oncology Nursing, vol. 15, no. 5, pp. 481–492, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. Å. Boström, H. Lindman, C. Swartling, B. Berne, and J. Bergh, “Potent corticosteroid cream (mometasone furoate) significantly reduces acute radiation dermatitis: results from a double-blind, randomized study,” Radiotherapy and Oncology, vol. 59, no. 3, pp. 257–265, 2001. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Schmuth, M. A. Wimmer, S. Hofer et al., “Topical corticosteroid therapy for acute radiation dermatitis: a prospective, randomized, double-blind study,” British Journal of Dermatology, vol. 146, no. 6, pp. 983–991, 2002. View at Publisher · View at Google Scholar · View at Scopus
  29. R. C. Miller, D. J. Schwartz, J. A. Sloan et al., “Mometasone furoate effect on acute skin toxicity in breast cancer patients receiving radiotherapy: a phase III double-blind, randomized trial from the North Central Cancer Treatment Group N06C4,” International Journal of Radiation Oncology Biology Physics, vol. 79, no. 5, pp. 1460–1466, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. M. E. Potera, D. P. Lookingbill, and J. A. Stryker, “Prophylaxis of radiation dermatitis with a topical cortisone cream,” Radiology, vol. 143, no. 3, pp. 775–777, 1982. View at Publisher · View at Google Scholar · View at Scopus
  31. J. Richardson, J. E. Smith, M. McIntyre, R. Thomas, and K. Pikington, “Aloe vera for preventing radiation-induced skin reactions: a systematic literature review,” Clinical Oncology, vol. 17, no. 6, pp. 478–484, 2005. View at Publisher · View at Google Scholar · View at Scopus
  32. P. Pommier, F. Gomez, M. P. Sunyach, A. D'Hombres, C. Carrie, and X. Montbarbon, “Phase III randomized trial of Calendula Officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer,” Journal of Clinical Oncology, vol. 22, no. 8, pp. 1447–1453, 2004. View at Publisher · View at Google Scholar · View at Scopus
  33. L. Sharp, K. Finnilä, H. Johansson, M. Abrahamsson, T. Hatschek, and M. Bergenmar, “No differences between Calendula cream and aqueous cream in the prevention of acute radiation skin reactions—results from a randomised blinded trial,” European Journal of Oncology Nursing, vol. 17, no. 4, pp. 429–435, 2013. View at Publisher · View at Google Scholar · View at Scopus
  34. V. Liguori, C. Guillemin, G. F. Pesce, R. O. Mirimanoff, and J. Bernier, “Double-blind, randomized clinical study comparing hyaluronic acid cream to placebo in patients treated with radiotherapy,” Radiotherapy & Oncology, vol. 42, no. 2, pp. 155–161, 1997. View at Publisher · View at Google Scholar · View at Scopus
  35. M. C. Leonardi, S. Gariboldi, G. B. Ivaldi et al., “A double-blind, randomised, vehicle-controlled clinical study to evaluate the efficacy of MAS065D in limiting the effects of radiation on the skin: interim analysis,” European Journal of Dermatology, vol. 18, no. 3, pp. 317–321, 2008. View at Publisher · View at Google Scholar · View at Scopus
  36. C. Pinnix, G. H. Perkins, E. A. Strom et al., “Topical hyaluronic acid vs. standard of care for the prevention of radiation dermatitis after adjuvant radiotherapy for breast cancer: single-blind randomized phase III clinical trial,” International Journal of Radiation Oncology Biology, Physics, vol. 83, no. 4, pp. 1089–1094, 2012. View at Publisher · View at Google Scholar · View at Scopus
  37. R. J. Chan, E. Larsen, and P. Chan, “Re-examining the evidence in radiation dermatitis management literature: an overview and a critical appraisal of systematic reviews,” International Journal of Radiation Oncology Biology Physics, vol. 84, no. 3, pp. e357–e362, 2012. View at Publisher · View at Google Scholar · View at Scopus
  38. S. Kumar, E. Juresic, M. Barton, and J. Shafiq, “Management of skin toxicity during radiation therapy: a review of the evidence,” Journal of Medical Imaging and Radiation Oncology, vol. 54, no. 3, pp. 264–279, 2010. View at Publisher · View at Google Scholar · View at Scopus
  39. S. D'Haese, T. Bate, S. Claes, A. Boone, V. VanVoorden, and F. Efficace, “Management of skin reactions during radiotherapy: a study of nursing practice,” European Journal of Cancer Care, vol. 14, no. 1, pp. 28–42, 2005. View at Publisher · View at Google Scholar · View at Scopus
  40. B.-W. Huang, M.-T. Chiang, H.-T. Yao, and W. Chiang, “The effect of adlay oil on plasma lipids, insulin and leptin in rat,” Phytomedicine, vol. 12, no. 6-7, pp. 433–439, 2005. View at Publisher · View at Google Scholar · View at Scopus
  41. A. G. Morganti, C. Digesù, S. Panunzi et al., “Radioprotective effect of moderate wine consumption in patients with breast carcinoma,” International Journal of Radiation Oncology, Biology, Physics, vol. 74, no. 5, pp. 1501–1505, 2009. View at Publisher · View at Google Scholar · View at Scopus
  42. T. Hijal, A. A. Al Hamad, T. Niazi et al., “Hypofractionated radiotherapy and adjuvant chemotherapy do not increase radiation-induced dermatitis in breast cancer patients,” Current Oncology, vol. 17, no. 5, pp. 22–27, 2010. View at Google Scholar · View at Scopus