Application of Antrodia camphorata Promotes Rat’s Wound Healing In Vivo and Facilitates Fibroblast Cell Proliferation In Vitro

Figure 4

Histological sections of wound tissue stained with Masson’s trichrome at day 14 after wounding in rats topically dressed with (a) 0.2 mL of vehicle, gum acacia, showed remarkably wide wound closure area (orange arrow) and granulation tissue (GT) contained less collagen deposition. (b) 0.2 mL of Antrodia camphorata (100 mg/mL) showed remarkably moderate wound closure and granulation tissue contained less collagen deposition. (c) 0.2 mL of Antrodia camphorata (200 mg/mL) showed narrow wound closure area and thin epidermis and granulation tissue contained remarkably more collagen deposition compared to vehicle group. (d) 0.2 mL of Intrasite gel showed very narrow wound closure area and granulation tissue contained remarkably more collagen deposition compared to vehicle group. S = scab, E = epidermis, and GT = granulation tissue (magnification 20x).

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