Application of Antrodia camphorata Promotes Rat’s Wound Healing In Vivo and Facilitates Fibroblast Cell Proliferation In Vitro

Figure 5

High magnification of wound granulation tissue stained with Masson’s trichrome at day 14 after wounding in rats dressed with (a) 0.2 mL of vehicle, gum acacia, showed more inflammatory cells and less fibroblast and collagen deposition. (b) 0.2 mL of Antrodia camphorata (100 mg/mL) showed remarkably less inflammatory cells and moderately more fibroblast and collagen deposition compared to vehicle group. (c) 0.2 mL of Antrodia camphorata (200 mg/mL) showed remarkably less inflammatory cells and more fibroblast and collagen deposition compared to vehicle group. (d) 0.2 mL of Intrasite gel showed remarkably more collagen fibers and fibroblasts and less inflammatory cells compared to vehicle group. C = collagen, IC = inflammatory cells, and BV = blood vessels (100x magnification).

(a)

(b)

(c)

(d)