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Evidence-Based Complementary and Alternative Medicine
Volume 2015, Article ID 321091, 8 pages
http://dx.doi.org/10.1155/2015/321091
Review Article

Pharmacogenomics and Herb-Drug Interactions: Merge of Future and Tradition

1Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
2Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University, Changsha 410078, China

Received 1 December 2014; Revised 20 January 2015; Accepted 21 January 2015

Academic Editor: Roja Rahimi

Copyright © 2015 Mou-Ze Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The worldwide using of herb products and the increasing potential herb-drug interaction issue has raised enthusiasm on discovering the underlying mechanisms. Previous review indicated that the interactions may be mediated by metabolism enzymes and transporters in pharmacokinetic pathways. On the other hand, an increasing number of studies found that genetic variations showed some influence on herb-drug interaction effects whereas these genetic factors did not draw much attention in history. We highlight that pharmacogenomics may involve the pharmacokinetic or pharmacodynamic pathways to affect herb-drug interaction. We are here to make an updated review focused on some common herb-drug interactions in association with genetic variations, with the aim to help safe use of herbal medicines in different individuals in the clinic.