[Retracted] Sagunja-Tang Improves Lipid Related Disease in a Postmenopausal Rat Model and HepG2 Cells

Table 4

NASH scores in a rat model of menopausal hyperlipidemia.

	Sham	OVX-Con	OVX-SV	OVX-SGJT (50)	OVX-SGJT (150)	OVX-SGJT (450)
	(n = 5)	(n = 5)	(n = 5)	(n = 5)	(n = 5)	(n = 5)
Steatosis	0.20 ± 0.20	2.50 ± 0.20	1.20 ± 0.20^c	1.00 ± 0.20^c	0.80 ± 0.20^c	1.80 ± 0.37^b
Lobular inflammation	1.00 ± 0.00	2.40 ± 0.24	1.40 ± 0.24^b	1.20 ± 0.20^b	1.00 ± 0.45^b	1.40 ± 0.24^b
Hepatocellular ballooning	1.00 ± 0.00	2.30 ± 0.20	1.00 ± 0.00^d	1.40 ± 0.24^c	0.40 ± 0.24^e	1.80 ± 0.20^b

Sham, Sham rats fed a high-fat (HFD), high-cholesterol diet (HCD); OVX-Con, OVX rats fed a high-fat (HFD), high-cholesterol diet (HCD); OVX-SV, OVX rats fed a high-fat (HFD), high-cholesterol diet (HCD) supplemented with simvastatin (20 mg/kg); OVX-SGJT, OVX rats fed a high-fat (HFD), high-cholesterol diet (HCD) supplemented with SGJT (50, 150, 450 mg/kg). After 8 weeks, steatosis, and lobular inflammation and hepatocellular ballooning contents were measured. Total scores of each component were then added to determine the presence or absence of NASH, with score ≥5 diagnosed as NASH, and scores ≤2 defined as not NASH. Values are expressed as means ± SD (n = 5). Significantly different between the sham and OVX-Con at P < 0.01, (two-sample -test). Values not sharing a common alphabet as superscripts are significantly different from each other at the level of P < 0.05 (ANOVA followed by Duncan’s test).