Ethanol Extract of Perilla frutescens Suppresses Allergen-Specific Th2 Responses and Alleviates Airway Inflammation and Hyperreactivity in Ovalbumin-Sensitized Murine Model of Asthma

Figure 5

Histamine and eotaxin contents in BALF of OVA-sensitized/challenged BALB/c mice supplemented with the different extracts of Perilla frutescens. OVA-sensitized mice were fed with water or ethanol extracts of Perilla frutescens for 3 weeks, respectively, and BALF was collected after aerosolized OVA (50 mg/mL) inhalation challenge. The concentrations of histamine (a) and eotaxin (b) in BALF were determined by ELISA. Values represent mean ± SD, = 7~8 for each OVA-sensitized group, and for the PBS group as negative control. Statistical analysis was performed with Student’s -test, compared with the control group.

(a)

(b)