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Evidence-Based Complementary and Alternative Medicine
Volume 2015, Article ID 350703, 8 pages
Research Article

A Metabolomics Approach to Stratify Patients Diagnosed with Diabetes Mellitus into Excess or Deficiency Syndromes

1Center of Chinese Medicine Therapy and Systems Biology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
2Institute of Digestive Disease, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China

Received 23 June 2014; Accepted 29 July 2014

Academic Editor: Wei Jia

Copyright © 2015 Tao Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Figure S1 presents an overview of data analysis in the manuscript. Table S1 shows there is no significant difference of the four differential metabolites between groups with Mann-Whitney Test Analysis (P > 0.05). Furthermore, the KOPLS model also shows that no matter the age > 70 or ≤ 70 (n = 161 versus 134), deficiency group and excess group could be distinctly separated on the classification in Figure S2. Similar results are also found in BMI ≥ 25 or < 25 (n = 153 versus 142) in Figure S3.). The results prompts that the age and BMI with significant difference between deficiency and excess groups do not affect the final metabolomics results.

  1. Supplementary Material