ACE Reduces Metabolic Abnormalities in a High-Fat Diet Mouse Model
Table 3
Oxidative stress and antioxidant parameters.
Groups
Naive
Control
ACE 100
ACE 200
Curcumin 50
Serum
ROS (U/mL)
772 ± 88
1,428 ± 402##
1,091 ± 211
1,041 ± 368
976 ± 358
Liver
ROS (U/mg protein)
127.9 ± 26.9
180.5 ± 57.8##
166.4 ± 54.1
96.6 ± 20.3
109.3 ± 17.8
MDA (μM/mg protein)
2.9 ± 1.7
42.1 ± 20.0###
10.0 ± 18.2
5.13 ± 4.5
2.8 ± 1.2
Protein carbonyl (μM/mg protein)
50.5 ± 19.3
85.9 ± 21.5##
67.3 ± 8.9
74.5 ± 10.8
64.4 ± 10.0
TAC (μM/mg protein)
901 ± 138
648 ± 111##
521 ± 128
714 ± 263
550 ± 119
Total GSH (mM/mg protein)
2.31 ± 0.18
1.88 ± 0.17###
2.25 ± 0.33
1.54 ± 0.44
1.57 ± 0.29
GSH-px (U/mg protein)
8.78 ± 2.71
10.88 ± 3.70
10.62 ± 3.21
14.75 ± 8.11
25.04 ± 7.80
GSH-rd (U/mg protein)
7.7 ± 1.62
5.82 ± 0.43##
6.8 ± 1.20
7.23 ± 1.93
5.37 ± 0.87
SOD (U/mg protein)
181.1 ± 30.6
117.1 ± 16.4##
143.9 ± 24.8
136.7 ± 14.6
124.1 ± 35.5
Catalase (U/mg protein)
923 ± 99
1,168 ± 195##
1,421 ± 630
1,388 ± 455
1,060 ± 244
Data were expressed as mean ± standard deviation (SD). ##P < 0.01, ###P < 0.001 compared with naive group. P < 0.05, P < 0.01, and < 0.001 compared with control group. ACE (water extract of Artemisia iwayomogi and Curcuma longa).
