Naringin Attenuates Autophagic Stress and Neuroinflammation in Kainic Acid-Treated Hippocampus In Vivo

Figure 1

The antiseizure effects of naringin on KA-induced seizures in mice. Mice received twice intraperitoneal injection of naringin (80 mg/kg) at 1 day and 1 h before KA treatment, and then they were treated with intrahippocampal injection of KA to induce seizures. Treatment with naringin significantly increased latency of seizure onset in mice treated with KA compared to KA alone (a). , significantly different from KA alone (-test, for each group). The frequency of SRS evaluated for 2 weeks starting 3 weeks after KA treatment. Mice that received naringin for 5 weeks showed a significant decrease in the frequency of SRS compared to KA alone (b). , significantly different from KA alone (-test, for each group). KA: KA-treated mice; NAR(80)+KA: 80 mg/kg naringin with KA-treated mice.

(a)

(b)