An Overview of Meta-Analyses of Danhong Injection for Unstable Angina

Table 1

Characteristics of included trials.

Author; Year	Electronic databases	Assessment tool of primary studies	Study type	Study time	Number of trails; (participants)	Experiment group; (participants)	Control group; (participants)	Course; (d)	Main outcome	Adverse events	Authors’ conclusion
Wangand Hu, 2010 [19]	VIP, CNKI, and Wanfang	Jadad	RCT	2000–2009	13; (1183)	CMT plus DHI; (623)	CMT; (560)	7–15	Effectiveness for RAS and ECG	Yes	Effectiveness of RAS and ECG Incidence of heart event
Xu et al.,; 2010 [20]	Cochrane Library, Medline, Embase, CBM disc, and CNKI	Jadad	RCT	1991–2010	9; (771)	CMT plus DHI; (401)	CMT; (370)	10–15	Effectiveness for RAS and ECG	No	Effectiveness and safety for UA
Xu et al.,; 2011 [21]	Cochrane Library, Medline, Embase, CBM disc, and CNKI	Jadad	RCT	1991–2009	19; (1940)	CMT plus DHI; (991)	CMT; (949)	10–21	Effectiveness for RAS and ECG	Yes	Effectiveness for UA
Yang et al.,; 2011 [22]	CNKI, Wanfang, VIP, and CBM disc	NM	RCT	2000–2010	12; (1337)	CMT plus DHI; (NM)	CMT; (NM)	NM	Effectiveness for ECG and RAS	NM	Effectiveness and safety for UA
Cui et al.,; 2012 [23]	Pubmed, Medline, CNKI, Wanfang, and Cochrane Library	Jadad	RCT	Up to 2010	23; (2675)	CMT plus DHI; (1382)	CMT; (1293)	10–28	Effectiveness for ECG and RAS; Regulation of HDL-C, LDL-C, and; HS-CRP	NM Or no	Effectiveness for ECG Regulation of HDL-C, LDL-C, and HS-CRP

DHI: Danhong injection; NM: not mentioned; CMT: conventional medicine treatment, including the combination of platelet aggregation inhibitor (aspirin), nitrates, beta-blockers, calcium channel blockers, and ACE inhibitors; RAS: resolution of angina symptoms; ECG: electrocardiogram; HDL-C: high density lipoprotein-cholesterol; LDL-C: low density lipoprotein-cholesterol; HS-CRP: high sensitive C-reactive protein; indicates the intervention of 2 trials that were conventional medicine treatment plus DHI versus conventional medicine treatment plus Danshen injection; CNKI: China National Knowledge Infrastructure; CBM disc: Chinese Biology Medicine disc.