Berberine Reduces Neurotoxicity Related to Nonalcoholic Steatohepatitis in Rats

Figure 4

Light microscope examination of liver tissues: photomicrograph of liver sections of the different groups using (H&E 40x magnification); (a) section of the liver tissue of control group showed normal hepatic cells radiating around the central vein (Cv) and separated by sinusoids (S). (b) In the CCL₄-NASH induced group, the liver had hepatic cells radiating around the central vein (Cv) separated by sinusoids (S) and the black arrows refer to inflammatory reaction with polymorphonuclear leukocytes surrounding hepatocytes. (c) Section of liver tissue of berberine control group showed a normal histological structure of the hepatic cords, sinusoids (S), and central vein (Cv). (d) The CCL₄-NASH induced group treated with berberine had liver with little vacuolation of hepatocytes and central veins with RBCs (black arrow).

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