Berberine Reduces Neurotoxicity Related to Nonalcoholic Steatohepatitis in Rats

Figure 5

Calculated 2D compound properties of berberine compared to reference drugs; here is the reports of 2D molecular analysis of the three compounds, donepezil, berberine, and atorvastatin, showing different parameters controlling their activity. TPSA (topological polar surface area), values (reflect the overall lipophilicity), b_rotN (number of rotatable bonds), and VSA_hyd (approximation to the sum of VDW surface of the hydrophobic atoms).