Berberine Reduces Neurotoxicity Related to Nonalcoholic Steatohepatitis in Rats
Table 1
Mean levels of blood liver function tests and lipid profile in control, NASH, and berberine treated groups.
Groups
AST (U/L)
ALT (U/L)
AST/ALT
RBP-4 (pg/L)
TG mg/dL
Cholesterol mg/dL
LDL mg/dL
VLDL mg/dL
LDL/HDL
Brain cholesterol (mg/g)
Control
12 ± 1.2
10 ± 0.4
1.2
200.5 ± 19
56 ± 7.5
70 ± 4.5
40 ± 2.3
11 ± 1.22
2.67
90 ± 10
Berberine control
13 ± 2.1
8.5 ± 0.32
1.53
190 ± 20
40 ± 2.3
50 ± 2.3
30 ± 2.1
8 ± 2.1
2.5
98 ± 12
NASH
30 ± 3.2
45 ± 4.2
0.67
600 ± 76
180 ± 23
200 ± 23
140 ± 10
36 ± 3.1
5.8
238.7 ± 34.9
Berberine treatment
15 ± 2.5
12 ± 4.2
1.25
230 ± 8.5
70 ± 11
80 ± 6.7
40 ± 5.5
14 ± 2.1
1.54
130 ± 9.9
Values are reported as means ± SD of rat groups (10 rats each) with different degrees of significance at . Lowest value of significance. Highest value of significance. If two groups have the same letters, it means no significant difference is detected.
