Antiviral Activities of Several Oral Traditional Chinese Medicines against Influenza Viruses

Figure 4

Effects of Xiaoqinglong mixture on MAPK pathway and interferon production. (a) Xiaoqinglong mixture activated p38 MAPK and phospho-JNK/SAPK pathway with concentration of 40 μL/mL. (b–d) The effect of Xiaoqinglong mixture on NF-κB and AP-1 nuclear transcription factor with concentration of 40 μL/mL. (e-f) Xiaoqinglong mixture enhanced the RNA expression of IFN-α and IFN-β in a dose-dependent manner. Oseltamivir: 10 μg/mL; 8: three diluted concentrations of 40 μL/mL, 20 μL/mL, and 10 μL/mL, respectively. (g) Xiaoqinglong mixture enhanced the protein expression of ISGs in a dose-dependent manner. (h) Supposed schematic of Xiaoqinglong mixture activated IFN regulation system. Results are expressed as mean ± SD; , , and , compared with mock control; , , and , compared with virus control.

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