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Evidence-Based Complementary and Alternative Medicine
Volume 2015 (2015), Article ID 369021, 12 pages
http://dx.doi.org/10.1155/2015/369021
Research Article

Luoyutong Treatment Promotes Functional Recovery and Neuronal Plasticity after Cerebral Ischemia-Reperfusion Injury in Rats

1Cerebrovascular Diseases Research Institute, Xuanwu Hospital, Capital Medical University, Ministry of Education, 45 Changchun Street, Beijing 100053, China
2Department of Traditional Chinese Medicine, Xuanwu Hospital, Capital Medical University, Ministry of Education, 45 Changchun Street, Beijing 100053, China
3Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China
4Key Laboratory of Neurodegenerative Diseases (Capital Medical University), Ministry of Education, 45 Changchun Street, Beijing 100053, China
5Department of Neurology, Xuanwu Hospital, Capital Medical University, Ministry of Education, 45 Changchun Street, Beijing 100053, China

Received 9 September 2015; Revised 5 November 2015; Accepted 15 November 2015

Academic Editor: Shan-Yu Su

Copyright © 2015 Ning-qun Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Luoyutong (LYT) capsule has been used to treat cerebrovascular diseases clinically in China and is now patented and approved by the State Food and Drug Administration. In this retrospective validation study we investigated the ability of LYT to protect against cerebral ischemia-reperfusion injury in rats. Cerebral ischemia-reperfusion injury was induced by middle cerebral artery occlusion followed by reperfusion. Capsule containing LYT (high dose and medium dose) as treatment group and Citicoline Sodium as positive control treatment group were administered daily to rats 30 min after reperfusion. Treatment was continued for either 3 days or 14 days. A saline solution was administered to control animals. Behavior tests were performed after 3 and 14 days of treatment. Our findings revealed that LYT treatment improved the neurological outcome, decreased cerebral infarction volume, and reduced apoptosis. Additionally, LYT improved neural plasticity, as the expression of synaptophysin, microtubule associated protein, and myelin basic protein was upregulated by LYT treatment, while neurofilament 200 expression was reduced. Moreover, levels of brain derived neurotrophic factor and basic fibroblast growth factor were increased. Our results suggest that LYT treatment may protect against ischemic injury and improve neural plasticity.