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Evidence-Based Complementary and Alternative Medicine
Volume 2015 (2015), Article ID 369631, 6 pages
http://dx.doi.org/10.1155/2015/369631
Research Article

Effects of Cordyceps sinensis on the Expressions of NF-κB and TGF-β1 in Myocardium of Diabetic Rats

1Department of Endocrinology, The Fifth Central Hospital of Tianjin, Tianjin 300450, China
2Community Health Service Center of Hu Jiayuan Street, Binhai New District, Tianjin 300454, China
3Graduate School of Tianjin Medical University, Tianjin 300070, China
4Department of Endocrinology, General Hospital of Tianjin Medical University, Tianjin 300052, China

Received 23 March 2015; Revised 26 July 2015; Accepted 2 August 2015

Academic Editor: Ken Yasukawa

Copyright © 2015 You-you Gu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. M. Thomas, Q. C. Yong, R. M. Rosa et al., “Cardiac-specific suppression of NF-κB signaling prevents diabetic cardiomyopathy via inhibition of the renin-angiotensin system,” American Journal of Physiology: Heart and Circulatory Physiology, vol. 307, no. 7, pp. H1036–H1045, 2014. View at Publisher · View at Google Scholar · View at Scopus
  2. Y. F. Chen, C. Y. Wang, W. M. Li et al., “Effect of Huangqi gegen decoction (HGD) on TGF-beta1/Smad3 pathway in diabetic cardiomyopathy rats,” Zhong Yao Cai, vol. 35, no. 11, pp. 1809–1813, 2012. View at Google Scholar
  3. J. Cui, M.-C. Qiu, D.-Q. Li, X. Zhang, J.-S. Zhang, and P. Zhang, “The protective effects of cyclosporine A on aortic immunological injuries in STZ-induced diabetic rats,” Zhonghua Xin Xue Guan Bing Za Zhi, vol. 38, no. 5, pp. 440–444, 2010. View at Google Scholar · View at Scopus
  4. W. C. Kan, H. Y. Wang, C. C. Chien et al., “Effects of extract from solid-state fermented Cordyceps sinensis on type 2 diabetes mellitus,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 743107, 10 pages, 2012. View at Publisher · View at Google Scholar
  5. M.-L. Yang, P.-C. Kuo, T.-L. Hwang, and T.-S. Wu, “Anti-inflammatory principles from Cordyceps sinensis,” Journal of Natural Products, vol. 74, no. 9, pp. 1996–2000, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. Y. Wang, W. Sun, B. Du et al., “Therapeutic effect of MG-132 on diabetic cardiomyopathy is associated with its suppression of proteasomal activities: roles of Nrf2 and NF-κB,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 304, no. 4, pp. H567–H578, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. H. Cheng, Y. Bo, W. Shen et al., “Leonurine ameliorates kidney fibrosis via suppressing TGF-β and NF-κB signaling pathway in UUO mice,” International Immunopharmacology, vol. 25, no. 2, pp. 406–415, 2015. View at Publisher · View at Google Scholar
  8. N. Mariappan, C. M. Elks, S. Sriramula et al., “NF-κB-induced oxidative stress contributes to mitochondrial and cardiac dysfunction in type II diabetes,” Cardiovascular Research, vol. 85, no. 3, pp. 473–483, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Wu, M. Han, J. Li et al., “17β-estradiol inhibits angiotensin II-induced cardiac myofibroblast differentiation,” European Journal of Pharmacology, vol. 616, no. 1–3, pp. 155–159, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. J. T. Bazzaz, M. M. Amoli, Z. Taheri, B. Larijani, V. Pravica, and I. V. Hutchinson, “TGF-β1 and IGF-I gene variations in type 1 diabetes microangiopathic complications,” Journal of Diabetes and Metabolic Disorders, vol. 13, article 45, 2014. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. Sun, J. Zhang, J. Q. Zhang, and F. J. A. Ramires, “Local angiotensin II and transforming growth factor-betal in renal fibrosis of rats,” Hypertension, vol. 35, no. 5, pp. 1078–1084, 2000. View at Publisher · View at Google Scholar · View at Scopus
  12. Y. Wang, D. Liu, H. Zhao et al., “Cordyceps sinensis polysaccharide CPS-2 protects human mesangial cells from PDGF-BB-induced proliferation through the PDGF/ERK and TGF-β1/Smad pathways,” Molecular and Cellular Endocrinology, vol. 382, no. 2, pp. 979–988, 2014. View at Publisher · View at Google Scholar · View at Scopus
  13. L.-Z. Meng, B.-Q. Lin, B. Wang et al., “Mycelia extracts of fungal strains isolated from Cordyceps sinensis differently enhance the function of RAW 264.7 macrophages,” Journal of Ethnopharmacology, vol. 148, no. 3, pp. 818–825, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. J.-K. Yan, W.-Q. Wang, and J.-Y. Wu, “Recent advances in Cordyceps sinensis polysaccharides: mycelial fermentation, isolation, structure, and bioactivities: a review,” Journal of Functional Foods, vol. 6, no. 1, pp. 33–47, 2014. View at Publisher · View at Google Scholar · View at Scopus