Evidence-Based Complementary and Alternative Medicine / 2015 / Article / Fig 2

Research Article

Antiosteoporosis Activity of New Oriental Medicine Preparation (Kyungokgo Mixed with Water Extract of Hovenia dulcis) on the Ovariectomized Mice

Figure 2

Effect of HD (Hovenia dulsis) on trabecular morphometric parameters in proximal tibia and distal femur of OVX mice. Mice were treated with vehicle, HD (100, 300 mg/kg/day, p.o) for 6 weeks. (a) Bone volume/tissue volume (BV/TV), bone surface/tissue volume (BS/TV), bone surface/Bone volume (BS/BV), structure model index (SMI), trabecular bone pattern factor (Tb.Pf), trabecular thickness (Tb.Th), trabecular number (Tb.N), and trabecular separation (Tb.Sp) as analyzed with micro-CT Skyscan CTAn software. Data are expressed as mean SD (). *, **, and *** versus OVX group (femur); #, ##, and ### versus sham group (femur); , , and versus OVX group (tibia); , , and versus sham group (tibia). (b) Effect of HD on BMD of femur and tibia of OVX mice. Data are expressed as means SD (). *, **, and *** versus OVX group; #, ##, and ### versus sham group. (c) Representative two-dimensional images of the tibia and femur in the SHAM, OVX, HD 100, and HD 300 groups.