Antiosteoporosis Activity of New Oriental Medicine Preparation (Kyungokgo Mixed with Water Extract of Hovenia dulcis) on the Ovariectomized Mice
Effect of HD (Hovenia dulsis) on trabecular morphometric parameters in proximal tibia and distal femur of OVX mice. Mice were treated with vehicle, HD (100, 300 mg/kg/day, p.o) for 6 weeks. (a) Bone volume/tissue volume (BV/TV), bone surface/tissue volume (BS/TV), bone surface/Bone volume (BS/BV), structure model index (SMI), trabecular bone pattern factor (Tb.Pf), trabecular thickness (Tb.Th), trabecular number (Tb.N), and trabecular separation (Tb.Sp) as analyzed with micro-CT Skyscan CTAn software. Data are expressed as mean SD (). *, **, and *** versus OVX group (femur); #, ##, and ### versus sham group (femur); , , and versus OVX group (tibia); , , and versus sham group (tibia). (b) Effect of HD on BMD of femur and tibia of OVX mice. Data are expressed as means SD (). *, **, and *** versus OVX group; #, ##, and ### versus sham group. (c) Representative two-dimensional images of the tibia and femur in the SHAM, OVX, HD 100, and HD 300 groups.