Evidence-Based Complementary and Alternative Medicine / 2015 / Article / Tab 5

Research Article

Effects of a Proprietary Standardized Orthosiphon stamineus Ethanolic Leaf Extract on Enhancing Memory in Sprague Dawley Rats Possibly via Blockade of Adenosine A2A Receptors

Table 5

Results of in vitro adenosine A2A and adenosine A1 assays.

AssayConcentration (g/mL)Inhibition (%)IC50 (g/mL)

Adenosine A2A binding assay 151760.07
15074

Adenosine A2A functional assay antagonist31451.5
3026
30098

Increase in cAMP (%)
Adenosine A2A functional assay agonist3−1
30−3
300−8

Adenosine A1 functional assay antagonist activity3095.1
300
300100

Reduction in neurogenic twitch (%)
Adenosine A1 functional assay agonist activity35
3012
30029

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