Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2015 (2015), Article ID 379418, 8 pages
http://dx.doi.org/10.1155/2015/379418
Research Article

Mori Folium and Mori Fructus Mixture Attenuates High-Fat Diet-Induced Cognitive Deficits in Mice

1Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 130-701, Republic of Korea
2Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 130-701, Republic of Korea
3Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 130-701, Republic of Korea
4Department of Food and Nutrition, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 130-701, Republic of Korea

Received 10 December 2014; Accepted 12 March 2015

Academic Editor: Youn C. Kim

Copyright © 2015 Hyo Geun Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. Li, Z. Wang, and Z. Zuo, “Chronic intermittent fasting improves cognitive functions and brain dtructures in mice,” PLoS ONE, vol. 8, no. 6, Article ID e66069, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. K. M. Flegal, “Excess deaths associated with obesity: cause and effect,” International Journal of Obesity, vol. 30, no. 8, pp. 1171–1172, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. J.-J. Chang, M.-J. Hsu, H.-P. Huang, D.-J. Chung, Y.-C. Chang, and C.-J. Wang, “Mulberry anthocyanins inhibit oleic acid induced lipid accumulation by reduction of lipogenesis and promotion of hepatic lipid clearance,” Journal of Agricultural and Food Chemistry, vol. 61, no. 25, pp. 6069–6076, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. M. M. Kaczmarczyk, A. S. Machaj, G. S. Chiu et al., “Methylphenidate prevents high-fat diet (HFD)-induced learning/memory impairment in juvenile mice,” Psychoneuroendocrinology, vol. 38, no. 9, pp. 1553–1564, 2013. View at Publisher · View at Google Scholar · View at Scopus
  5. C.-H. Peng, L.-K. Liu, C.-M. Chuang, C.-C. Chyau, C.-N. Huang, and C.-J. Wang, “Mulberry water extracts possess an anti-obesity effect and ability to inhibit hepatic lipogenesis and promote lipolysis,” Journal of Agricultural and Food Chemistry, vol. 59, no. 6, pp. 2663–2671, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. J. A. Luchsinger, M.-X. Tang, S. Shea, and R. Mayeux, “Caloric intake and the risk of Alzheimer disease,” Archives of Neurology, vol. 59, no. 8, pp. 1258–1263, 2002. View at Publisher · View at Google Scholar · View at Scopus
  7. D. Nair, V. Ramesh, and D. Gozal, “Adverse cognitive effects of high-fat diet in a murine model of sleep apnea are mediated by NADPH oxidase activity,” Neuroscience, vol. 227, pp. 361–369, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. M. A. Khan, A. A. Rahman, S. Islam et al., “A comparative study on the antioxidant activity of methanolic extracts from different parts of Morus alba L. (Moraceae),” BMC Research Notes, vol. 6, article 24, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. T. Katsube, M. Yamasaki, K. Shiwaku et al., “Effect of flavonol glycoside in mulberry (Morus alba L.) leaf on glucose metabolism and oxidative stress in liver in diet-induced obese mice,” Journal of the Science of Food and Agriculture, vol. 90, no. 14, pp. 2386–2392, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. T. Katsube, N. Imawaka, Y. Kawano, Y. Yamazaki, K. Shiwaku, and Y. Yamane, “Antioxidant flavonol glycosides in mulberry (Morus alba L.) leaves isolated based on LDL antioxidant activity,” Food Chemistry, vol. 97, no. 1, pp. 25–31, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Yoshida, S. Hiradate, T. Tsukamoto, K. Hatakeda, and A. Shirata, “Antimicrobial activity of culture filtrate of Bacillus amyloliquefaciens RC-2 isolated from mulberry leaves,” Phytopathology, vol. 91, no. 2, pp. 181–187, 2001. View at Publisher · View at Google Scholar · View at Scopus
  12. Y. Kobayashi, M. Miyazawa, A. Kamei, K. Abe, and T. Kojima, “Ameliorative effects of mulberry (Morus alba L.) leaves on hyperlipidemia in rats fed a high-fat diet: induction of fatty acid oxidation, inhibition of lipogenesis, and suppression of oxidative stress,” Bioscience, Biotechnology and Biochemistry, vol. 74, no. 12, pp. 2385–2395, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. J. Lee, K. Chae, J. Ha et al., “Regulation of obesity and lipid disorders by herbal extracts from Morus alba, Melissa officinalis, and Artemisia capillaris in high-fat diet-induced obese mice,” Journal of Ethnopharmacology, vol. 115, no. 2, pp. 263–270, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. A. V. Yadav, L. A. Kawale, and V. S. Nade, “Effect of Morus alba L. (mulberry) leaves on anxiety in mice,” Indian Journal of Pharmacology, vol. 40, no. 1, pp. 32–36, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. H. G. Kim, M. S. Ju, J. S. Shim et al., “Mulberry fruit protects dopaminergic neurons in toxin-induced Parkinson's disease models,” British Journal of Nutrition, vol. 104, no. 1, pp. 8–16, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. H. G. Kim and M. S. Oh, “Memory-enhancing effect of Mori Fructus via induction of nerve growth factor,” British Journal of Nutrition, vol. 110, no. 1, pp. 86–94, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. W. L. Li, H. C. Zheng, J. Bukuru, and N. de Kimpe, “Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus,” Journal of Ethnopharmacology, vol. 92, no. 1, pp. 1–21, 2004. View at Publisher · View at Google Scholar · View at Scopus
  18. P. Kaewkaen, T. Tong-Un, J. Wattanathorn, S. Muchimapura, W. Kaewrueng, and S. Wongcharoenwanakit, “Mulberry fruit extract protects against memory impairment and hippocampal damage in animal model of vascular dementia,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 263520, 9 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. X.-Y. Yang, G.-S. Park, M. H. Lee et al., “Toll-like receptor 4-mediated immunoregulation by the aqueous extract of Mori Fructus,” Phytotherapy Research, vol. 23, no. 12, pp. 1713–1720, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. H. H. Lim, S. O. Lee, S. Y. Kim, S. J. Yang, and Y. Lim, “Anti-inflammatory and antiobesity effects of mulberry leaf and fruit extract on high fat diet-induced obesity,” Experimental Biology and Medicine, vol. 238, no. 10, pp. 1160–1169, 2013. View at Publisher · View at Google Scholar · View at Scopus
  21. H. H. Lim, S. J. Yang, Y. Kim, M. S. Lee, and Y. Lim, “Combined treatment of mulberry leaf and fruit extract ameliorates obesity-related inflammation and oxidative stress in high fat diet-induced obese mice,” Journal of Medicinal Food, vol. 16, no. 8, pp. 673–680, 2013. View at Publisher · View at Google Scholar · View at Scopus
  22. J.-I. Karasawa, K. Hashimoto, and S. Chaki, “d-Serine and a glycine transporter inhibitor improve MK-801-induced cognitive deficits in a novel object recognition test in rats,” Behavioural Brain Research, vol. 186, no. 1, pp. 78–83, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. T. Pancani, K. L. Anderson, L. D. Brewer et al., “Effect of high-fat diet on metabolic indices, cognition, and neuronal physiology in aging F344 rats,” Neurobiology of Aging, vol. 34, no. 8, pp. 1977–1987, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. J. F. Guzowski, “Insights into immediate-early gene function in hippocampal memory consolidation using antisense oligonucleotide and fluorescent imaging approaches,” Hippocampus, vol. 12, no. 1, pp. 86–104, 2002. View at Publisher · View at Google Scholar · View at Scopus
  25. R. Paylor, R. S. Johnson, V. Papaioannou, B. M. Spiegelman, and J. M. Wehner, “Behavioral assessment of c-fos mutant mice,” Brain Research, vol. 651, no. 1-2, pp. 275–282, 1994. View at Publisher · View at Google Scholar · View at Scopus
  26. M. VanElzakker, R. D. Fevurly, T. Breindel, and R. L. Spencer, “Environmental novelty is associated with a selective increase in Fos expression in the output elements of the hippocampal formation and the perirhinal cortex,” Learning and Memory, vol. 15, no. 12, pp. 899–908, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. R. Molteni, R. J. Barnard, Z. Ying, C. K. Roberts, and F. Gómez-Pinilla, “A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning,” Neuroscience, vol. 112, no. 4, pp. 803–814, 2002. View at Publisher · View at Google Scholar · View at Scopus
  28. L. D. Pozzo-Miller, W. Gottschalk, L. Zhang et al., “Impairments in high-frequency transmission, synaptic vesicle docking, and synaptic protein distribution in the hippocampus of BDNF knockout mice,” Journal of Neuroscience, vol. 19, no. 12, pp. 4972–4983, 1999. View at Google Scholar · View at Scopus
  29. A. Becher, A. Drenckhahn, I. Pahner, M. Margittai, R. Jahn, and G. Ahnert-Hilger, “The synaptophysin-synaptobrevin complex: a hallmark of synaptic vesicle maturation,” Journal of Neuroscience, vol. 19, no. 6, pp. 1922–1931, 1999. View at Google Scholar · View at Scopus
  30. U. Schmitt, N. Tanimoto, M. Seeliger, F. Schaeffel, and R. E. Leube, “Detection of behavioral alterations and learning deficits in mice lacking synaptophysin,” Neuroscience, vol. 162, no. 2, pp. 234–243, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. E. Kim and M. Sheng, “PDZ domain proteins of synapses,” Nature Reviews Neuroscience, vol. 5, no. 10, pp. 771–781, 2004. View at Publisher · View at Google Scholar · View at Scopus
  32. M. Migaud, P. Charlesworth, M. Dempster et al., “Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein,” Nature, vol. 396, no. 6710, pp. 433–439, 1998. View at Publisher · View at Google Scholar · View at Scopus
  33. A. Ennaceur and K. Meliani, “A new one-trial test for neurobiological studies of memory in rats. III. Spatial vs. non-spatial working memory,” Behavioural Brain Research, vol. 51, no. 1, pp. 83–92, 1992. View at Publisher · View at Google Scholar · View at Scopus
  34. B. T. Jeon, E. A. Jeong, H. J. Shin et al., “Resveratrol attenuates obesity-associated peripheral and central inflammation and improves memory deficit in mice fed a high-fat diet,” Diabetes, vol. 61, no. 6, pp. 1444–1454, 2012. View at Publisher · View at Google Scholar · View at Scopus
  35. S. F. Nabavi, G. L. Russo, M. Daglia, and S. M. Nabavi, “Role of quercetin as an alternative for obesity treatment: you are what you eat!,” Food Chemistry, vol. 179, pp. 305–310, 2015. View at Publisher · View at Google Scholar
  36. M. Gao, Y. Ma, and D. Liu, “Rutin suppresses palmitic acids-triggered inflammation in macrophages and blocks high fat diet-induced obesity and fatty liver in mice,” Pharmaceutical Research, vol. 30, no. 11, pp. 2940–2950, 2013. View at Publisher · View at Google Scholar · View at Scopus
  37. S. K. Richetti, M. Blank, K. M. Capiotti et al., “Quercetin and rutin prevent scopolamine-induced memory impairment in zebrafish,” Behavioural Brain Research, vol. 217, no. 1, pp. 10–15, 2011. View at Publisher · View at Google Scholar · View at Scopus
  38. H. Guo, J. Guo, X. Jiang, Z. Li, and W. Ling, “Cyanidin-3-O-β-glucoside, a typical anthocyanin, exhibits antilipolytic effects in 3T3-L1 adipocytes during hyperglycemia: Involvement of FoxO1-mediated transcription of adipose triglyceride lipase,” Food and Chemical Toxicology, vol. 50, no. 9, pp. 3040–3047, 2012. View at Publisher · View at Google Scholar · View at Scopus
  39. L. Qin, J. Zhang, and M. Qin, “Protective effect of cyanidin 3-O-glucoside on beta-amyloid peptide-induced cognitive impairment in rats,” Neuroscience Letters, vol. 534, no. 1, pp. 285–288, 2013. View at Publisher · View at Google Scholar · View at Scopus