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Evidence-Based Complementary and Alternative Medicine
Volume 2015, Article ID 380615, 7 pages
Review Article

Gray Matter Volumes in Patients with Chronic Fatigue Syndrome

1Acupuncture and Tuina School, The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, No. 37 Shi’er Qiao Road, Chengdu, Sichuan 610075, China
2Institute for Social Medicine, Epidemiology and Health Economics, Charité University Medical Center, 10117 Berlin, Germany

Received 25 June 2014; Accepted 26 August 2014

Academic Editor: Cun-Zhi Liu

Copyright © 2015 Le-wei Tang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Chronic fatigue syndrome (CFS) is a debilitating and complex disorder characterized by profound fatigue with uncertain pathologic mechanism. Neuroimage may be an important key to unveil the central nervous system (CNS) mechanism in CFS. Although most of the studies found gray matter (GM) volumes reduced in some brain regions in CFS, there are many factors that could affect GM volumes in CFS, including chronic pain, stress, psychiatric disorder, physical activity, and insomnia, which may bias the results. In this paper, through reviewing recent literatures, we discussed these interferential factors, which overlap with the symptoms of CFS.