Protective Effect of Ethanolic Extract of Grape Pomace against the Adverse Effects of Cypermethrin on Weanling Female Rats

Figure 4

Photomicrograph of liver sections stained by haematoxylin and eosin (H&E) for histological changes (×400). Group 1 showing (a) normal histological structure of hepatic lobule from central vein (small arrow) and hepatic cords (large arrow). Groups II and III (grape pomace extract at 100 and 200 mg/kg. b.wt.) showing slight swelling of hepatocytes (arrow) (b and c). Group IV (cypermethrin at 25 mg/kg b.wt.) showing Kupffer cell activation (arrow) (c), karyomegaly (arrow) (d), Kupffer cells activation (small arrow) and portal infiltration with mononuclear inflammatory cells (large arrow) (e1), dysplasia of bile duct (arrow) and portal infiltration with inflammatory cells (large arrow) (e2), and hyperplasia and hyperactivation of epithelial lining bile duct (arrow) (e3). Group V (grape pomace extract at 100 mg/kg plus cypermethrin) showing Kupffer cell activation (arrow) (f). Group VI (grape pomace extract at 200 mg/kg b.wt. plus cypermethrin) showing slight activation of Kupffer cells (arrow) (g).