Farnesol, a Sesquiterpene Alcohol in Herbal Plants, Exerts Anti-Inflammatory and Antiallergic Effects on Ovalbumin-Sensitized and -Challenged Asthmatic Mice
Table 6
Effects of farnesol supplementation with different doses for 5 weeks on proinflammatory and anti-inflammatory cytokine secretions by peritoneal macrophages of OVA/AL-sensitized and -challenged BALB/c asthmatic mice.
Cytokines secreted by splenocytes
Groups
Treatment
Spon.
LPS
IL-1β (pg/mL)
DC
8.39 ± 3.88b
ND
FL
14.0 ± 3.4ab
11.8 ± 8.4ab
FM
11.9 ± 3.4b
18.5 ± 13.2a
FH
12.4 ± 8.0b
18.5 ± 13.2a
PC
11.5 ± 6.2b
8.3 ± 8.0bc
NSC
18.1 ± 10.6a
18.4 ± 16.1a
IL-6 (pg/mL)
DC
159 ± 95d
537 ± 156c
FL
270 ± 124cd
1047 ± 640bc
FM
943 ± 528a
1915 ± 1066a
FH
477 ± 278bc
1215 ± 786b
PC
515 ± 292bc
1076 ± 619bc
NSC
595 ± 338b
1231 ± 824b
TNF- (pg/mL)
DC
192 ± 73b
332 ± 126b
FL
250 ± 44ab
399 ± 74ab
FM
271 ± 85ab
506 ± 96a
FH
213 ± 141ab
356 ± 178b
PC
301 ± 98a
505 ± 177a
NSC
301 ± 148a
501 ± 215a
IL-10 (pg/mL)
DC
48.6 ± 35.1c
91.0 ± 41.0b
FL
91.7 ± 36.7ab
166 ± 59a
FM
129.3 ± 83.9a
193 ± 79a
FH
65.9 ± 47.2bc
151 ± 80a
PC
80.1 ± 46.0bc
159 ± 85a
NSC
80.9 ± 32.0bc
150 ± 63a
TNF-/IL-10 (pg/pg)
DC
3.89 ± 1.38ab
3.18 ± 1.36ab
FL
2.46 ± 0.52c
2.54 ± 0.98ab
FM
2.89 ± 1.60bc
2.13 ± 0.27b
FH
3.18 ± 0.88abc
2.15 ± 1.05b
PC
4.29 ± 1.98a
3.07 ± 1.04ab
NSC
3.63 ± 1.22abc
3.52 ± 1.92a
Values are means ± SD ( = 12–15). Values within same column not sharing a common small letter are significantly different () from each other and assayed by one-way ANOVA, followed by Duncan’s new multiple range test. The LOD of these kits used in this study was <3.9 pg/mL. “ND” means not detectable. NSC, nonsensitized control; DC, dietary control; PC, positive control; FL, low dose farnesol (0.003% in AIN-76 feed); FM, medium dose farnesol (0.017% in AIN-76 feed); FH, high dose farnesol (0.067% in AIN-76 feed).