Research Article
Ninety-Day Oral Toxicity Assessment of an Alternative Biopolymer for Controlled Release Drug Delivery Systems Obtained from Cassava Starch Acetate
Table 1
Effect of FCSA on urinary parameters of male and female Wistar rats exposed for 90 days.
| Parameters | Control | FCSA 3 mg/kg/day | FCSA 30 mg/kg/day | FCSA 300 mg/kg/day | Male | Female | Male | Female | Male | Female | Male | Female |
| Urine volume (mL/8 hours) | 9.76 ± 1.40 | 10.1 ± 1.34 | 10.5 ± 1.78 | 11.2 ± 1.74 | 12.0 ± 1.27 | 9.87 ± 1.31 | 11.2 ± 1.43 | 12.1 ± 1.64 | pH | 6.36 ± 0.04 | 6.27 ± 0.13 | 6.48 ± 0.12 | 6.43 ± 0.25 | 6.15 ± 0.12 | 6.56 ± 0.15 | 6.18 ± 0.12 | 6.52 ± 0.16 | Density (g/mL) | 1.02 ± 0.0 | 1.01 ± 0.0 | 1.01 ± 0.0 | 1.01 ± 0.0 | 1.02 ± 0.0 | 1.01 ± 0.0 | 1.02 ± 0.0 | 1.01 ± 0.0 | Conductivity (mS/cm) | 17.6 ± 0.16 | 13.1 ± 1.91 | 17.5 ± 0.62 | 13.9 ± 1.31 | 18.0 ± 0.17 | 14.1 ± 1.15 | 18.0 ± 0.30 | 14.1 ± 1.47 | Na+ (mmol/L) | 113 ± 1.12 | 120 ± 1.47 | 115 ± 0.93 | 121 ± 1.88 | 116 ± 1.27 | 118 ± 1.86 | 115 ± 2.04 | 119 ± 1.82 | K+ (mmol/L) | 35 ± 3.08 | 38.7 ± 2.07 | 34 ± 2.25 | 39.8 ± 1.66 | 37 ± 2.06 | 40.9 ± 1.59 | 35 ± 0.89 | 39.4 ± 1.26 |
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Values are expressed as mean ± S. E. M. of ten rats in each group in comparison to the control using one-way ANOVA followed by Bonferroni’s test.
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