Research Article
Ninety-Day Oral Toxicity Assessment of an Alternative Biopolymer for Controlled Release Drug Delivery Systems Obtained from Cassava Starch Acetate
Table 2
Effect of FCSA on hematological parameters of male and female Wistar rats exposed for 90 days.
| | Parameters | Control | FCSA 3 mg/kg/day | FCSA 30 mg/kg/day | FCSA 300 mg/kg/day | | Male | Female | Male | Female | Male | Female | Male | Female |
| | RBC (106/mL) | 7.9 ± 0.6 | 7.4 ± 0.1 | 8.6 ± 0.1 | 7.3 ± 0.1 | 8.5 ± 0.1 | 7.4 ± 0.1 | 8.5 ± 0.2 | 7.5 ± 0.1 | | Hemoglobin (g/mL) | 14.7 ± 0.4 | 14.4 ± 0.2 | 15.4 ± 0.2 | 14.3 ± 0.2 | 15.1 ± 0.1 | 14.4 ± 0.2 | 16.1 ± 0.8 | 14.7 ± 0.1 | | Hematocrit (%) | 43 ± 1.2 | 41 ± 0.6 | 45 ± 0.5 | 40 ± 0.6 | 44 ± 0.4 | 40 ± 0.7 | 44 ± 1.0 | 41 ± 0.4 | | MCV (fL) | 51.9 ± 0.5 | 56.2 ± 0.6 | 52.5 ± 0.5 | 55.7 ± 0.4 | 52.3 ± 0.5 | 55.1 ± 0.6 | 51.7 ± 0.3 | 55.8 ± 0.4 | | MCH (pg) | 17.7 ± 0.3 | 19.7 ± 0.3 | 18.0 ± 0.2 | 19.6 ± 0.2 | 17.8 ± 0.2 | 19.6 ± 0.3 | 18.8 ± 0.7 | 19.7 ± 0.2 | | MCHC (%) | 34 ± 0.3 | 35 ± 0.2 | 34 ± 0.2 | 35 ± 0.3 | 34 ± 0.2 | 36 ± 0.3 | 36 ± 1.3 | 35 ± 0.2 | | Platelets (103/mm3) | 1032 ± 79 | 951 ± 60 | 1045 ± 30 | 843 ± 120 | 1070 ± 42 | 881 ± 85 | 1098 ± 60 | 972 ± 71 | | WBC (103/mm3) | 4.4 ± 0.5 | 2.9 ± 0.3 | 5.4 ± 0.8 | 3.2 ± 0.8 | 4.4 ± 0.3 | 2.9 ± 0.5 | 4.1 ± 0.3 | 3.7 ± 1.3 | | Neutrophils (%) | 24.8 ± 4.0 | 26.3 ± 2.4 | 22.2 ± 1.4 | 21.5 ± 3.4 | 21.9 ± 2.1 | 28.1 ± 2.9 | 24.5 ± 3.8 | 23.8 ± 1.9 | | Lymphocytes (%) | 69.4 ± 3.4 | 67.3 ± 3.5 | 71.3 ± 2.9 | 71.6 ± 2.1 | 70.6 ± 1.7 | 65.5 ± 3.3 | 68.2 ± 2.3 | 69.4 ± 2.7 | | Monocytes (%) | 4.4 ± 0.7 | 5.5 ± 0.7 | 4.9 ± 1.2 | 6.1 ± 1.2 | 5.8 ± 0.9 | 5.3 ± 0.8 | 6.1 ± 1.1 | 5.8 ± 1.0 | | Eosinophils (%) | 1.4 ± 0.5 | 0.9 ± 0.3 | 1.6 ± 0.6 | 0.8 ± 0.2 | 1.7 ± 0.3 | 1.1 ± 0.5 | 1.2 ± 0.3 | 1.0 ± 0.3 |
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Values are expressed as mean ± S. E. M. of ten rats in each group in comparison to the control using one-way ANOVA followed by Bonferroni’s test.
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